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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2a
Synonym	CA2-47 alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A Alpha-2D adrenergic receptor Alpha-2AAR Alpha-2A adrenoreceptor Alpha-2A adrenoceptor adrenergic receptor Adrenergic alpha 2A receptor ADRA2R ADRA2 Adra-2a Adra-2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	450
Amino acid sequence	MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	P22909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL327
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL209985
Molecular formula	C19H32N4O3S
IUPAC name	N-[3-[4-[4-(propan-2-ylsulfonylamino)butyl]piperazin-1-yl]phenyl]acetamide
Molecular weight	396.55
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	1.7
Synonyms	SCHEMBL1385801 BDBM50187388 N-(3-{4-[4-(propane-2-sulfonylamino)-butyl]-piperazin-1-yl}-phenyl)-acetamide
Inchi Key	CPBIWHVJLGAGPZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H32N4O3S/c1-16(2)27(25,26)20-9-4-5-10-22-11-13-23(14-12-22)19-8-6-7-18(15-19)21-17(3)24/h6-8,15-16,20H,4-5,9-14H2,1-3H3,(H,21,24)
PubChem CID	10318597
ChEMBL	CHEMBL209985
IUPHAR	N/A
BindingDB	50187388
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	>10.0 %	PMID16722631	ChEMBL

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