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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL2113245
Molecular formula	C23H20Cl2N2O5
IUPAC name	N-[1-(1,3-benzodioxol-5-ylmethyl)piperidin-4-yl]-5,6-dichloro-4-oxochromene-2-carboxamide
Molecular weight	475.322
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.2
Synonyms	N/A
Inchi Key	AGBFMFGHXLRHBP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H20Cl2N2O5/c24-15-2-4-18-21(22(15)25)16(28)10-20(32-18)23(29)26-14-5-7-27(8-6-14)11-13-1-3-17-19(9-13)31-12-30-17/h1-4,9-10,14H,5-8,11-12H2,(H,26,29)
PubChem CID	11975436
ChEMBL	CHEMBL2113245
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	75.0 nM	PMID17064075	ChEMBL
IC50	4750.0 nM	PMID17064075	ChEMBL

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