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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(1A) dopamine receptor
Species	Bos taurus (Bovine)
Gene	DRD1
Synonym	Dopamine D1 receptor
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MRTLNTSTMEGTGLVAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTGPSEGNATSLGKTINNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPMECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNVVYLIPHAVGSSEGLKKEEAVGIAKPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProt	Q95136
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2967
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Moperone
Molecular formula	C22H26FNO2
IUPAC name	1-(4-fluorophenyl)-4-[4-hydroxy-4-(4-methylphenyl)piperidin-1-yl]butan-1-one
Molecular weight	355.453
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.0
Synonyms	1-(4-Fluorophenyl)-4-[4-hydroxy-4-(4-methylphenyl)-1-piperidinyl]-1-butanone 4'-Fluoro-4-(4-hydroxy-4-p-tolylpiperidino)butyrophenone;4'-Fluoro-4-(4-hydroxy-4-p-tolylpiperidino)butyrophenone CAS_1050-79-9 L000665 Moperone (INN) omega-(4-Hydroxy-4-p-tolylpiperidino)-p-fluorobutyrophenone 1-Butanone, 1-(4-fluorophenyl)-4-(4-hydroxy-4-(4-methylphenyl)-1-piperidinyl)- AGAHNABIDCTLHW-UHFFFAOYSA-N CTK8G1178 Meperon Moperonum p-Fluoro-4-(4'-hydroxy-4'-p-tolylpiperidino)butyrophenone 3871-82-7 (hydrochloride) BDBM81486 FT-0672517 Moperona [INN-Spanish] NCGC00188430-01 UNII-OU730881W5 1-(4-Fluorophenyl)-4-[4-hydroxy-4-(4-methylphenyl)-1-piperidinyl]-1-butanone # CHEBI:135500 Luvatren Moperone HCl OU730881W5 1-Butanone, 1-(4-fluorophenyl)-4-[4-hydroxy-4-(4-methylphenyl)-1-piperidinyl]- AKOS030254497 D02623 Methylperidol Moperonum [INN-Latin] R 1658 1-(3'-p-Fluorobenzoylpropyl)-4-hydroxy-4-p-tolylpiperidine 4'-Fluoro-4-(4-hydroxy-4-p-tolylpiperidino)butyrophenone Butyrophenone, 4'-fluoro-4-(4-hydroxy-4-p-tolylpiperidino)- gamma-(4-hydroxy-4-p-methylphenylpiperidino)-p-fluorobutyrophenone NSC_4249 ZINC538026 1-(4-fluorophenyl)-4-[4-hydroxy-4-(4-methylphenyl)piperidin-1-yl]butan-1-one AC1L1HQP CHEMBL2104700 Luvatrena Moperone [INN] p-Fluoro-4-(4'-hydroxy-4'-p-methylphenylpiperidino)butyrophenone 1050-79-9 API0003426 EINECS 213-887-6 Moperona Mopiperone SCHEMBL34340 [ Show all ]
Inchi Key	AGAHNABIDCTLHW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H26FNO2/c1-17-4-8-19(9-5-17)22(26)12-15-24(16-13-22)14-2-3-21(25)18-6-10-20(23)11-7-18/h4-11,26H,2-3,12-16H2,1H3
PubChem CID	4249
ChEMBL	N/A
IUPHAR	N/A
BindingDB	81486
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1200.0 nM	PMID995128, PMID9081563	BindingDB

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