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GPCR

NameDelta-type opioid receptor
SpeciesRattus norvegicus (Rat)
GeneOprd1
Synonymopioid receptor
OP1
DOR-1
DOR
DOPr
[ Show all ]
DiseaseN/A for non-human GPCRs
Length372
Amino acid sequenceMEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
UniProtP33533
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL269
IUPHAR317
DrugBankN/A

Ligand

NameCHEMBL329719
Molecular formulaC26H25NO4
IUPAC name(2S,13R)-22-(2-methylprop-2-enyl)-11,14-dioxa-22-azaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol
Molecular weight415.489
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP4.1
SynonymsBDBM50105776
22-(2-methylallyl)-(2S,13R)-11,14-dioxa-22-azaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaene-2,16-diol
Inchi KeyBBXYTWYGJXPWTP-RFTKNZGOSA-N
Inchi IDInChI=1S/C26H25NO4/c1-14(2)13-27-10-9-25-21-15-7-8-18(28)23(21)31-24(25)22-17(12-26(25,29)20(27)11-15)16-5-3-4-6-19(16)30-22/h3-8,20,24,28-29H,1,9-13H2,2H3/t20?,24-,25?,26+/m0/s1
PubChem CID44329698
ChEMBLCHEMBL329719
IUPHARN/A
BindingDB50105776
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki8.128 nMPMID15743203ChEMBL

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