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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Parathyroid hormone/parathyroid hormone-related peptide receptor
Species	Homo sapiens (Human)
Gene	PTH1R
Synonym	PTH1 receptor PTHR PTH/PTHrP type I receptor PTH/PTHr receptor PPR Parathyroid hormone 1 receptor PTHR1 [ Show all ]
Disease	N/A
Length	593
Amino acid sequence	MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
UniProt	Q03431
Protein Data Bank	6fj3, 3h3g, 3c4m
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 6fj3.
BioLiP	BL0161387, BL0433539,BL0433540, BL0161388, BL0143680,BL0143682, BL0143681,BL0143683
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1793
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	MLS001043278
Molecular formula	C25H14O7
IUPAC name	(7R)-10-hydroxy-7-(4-hydroxy-2-oxochromen-3-yl)-7H-chromeno[3,2-c]chromen-6-one
Molecular weight	426.38
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	3.6
Synonyms	(7R)-10-hydroxy-7-(2-hydroxy-4-keto-chromen-3-yl)-7H-chromeno[3,2-c]chromen-6-one AKOS032394822 MolPort-002-640-327 (7R)-10-hydroxy-7-(4-hydroxy-2-keto-chromen-3-yl)-7H-chromeno[3,2-c]chromen-6-one 10-Hydroxy-7-(4-hydroxy-2-oxo-2H-chromen-3-yl)-7H-chromeno[4,3-b]chromen-6-one HMS2765E11 (7R)-10-hydroxy-7-(2-hydroxy-4-oxo-1-benzopyran-3-yl)-7H-[1]benzopyrano[3,2-c][1]benzopyran-6-one BDBM66067 SMR000415059 (7R)-10-oxidanyl-7-(2-oxidanyl-4-oxidanylidene-chromen-3-yl)-7H-chromeno[3,2-c]chromen-6-one CHEMBL1532491 30301-41-8 (7R)-10-hydroxy-7-(2-hydroxy-4-oxochromen-3-yl)-7H-chromeno[3,2-c]chromen-6-one C25H14O7 ZINC15952310 (R)-10-hydroxy-7-(4-hydroxy-2-oxo-2H-chromen-3-yl)chromeno[4,3-b]chromen-6(7H)-one cid_16745841 [ Show all ]
Inchi Key	AFUYGYGEPFCEIX-LJQANCHMSA-N
Inchi ID	InChI=1S/C25H14O7/c26-12-9-10-13-18(11-12)30-23-15-6-2-4-8-17(15)32-25(29)21(23)19(13)20-22(27)14-5-1-3-7-16(14)31-24(20)28/h1-11,19,26-27H/t19-/m1/s1
PubChem CID	54677747
ChEMBL	CHEMBL1532491
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	14125.4 nM	PubChem BioAssay data set	ChEMBL

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