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GLASS

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GPCR

Name	G-protein coupled receptor 39
Species	Homo sapiens (Human)
Gene	GPR39
Synonym	GPR39
Disease	Diabetes
Length	453
Amino acid sequence	MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEV
UniProt	O43194
Protein Data Bank	N/A
GPCR-HGmod model	O43194
3D structure model	This predicted structure model is from GPCR-EXP O43194.
BioLiP	N/A
Therapeutic Target Database	T88531
ChEMBL	CHEMBL3091266
IUPHAR	105
DrugBank	N/A

Ligand

Name	zinc ion
Molecular formula	Zn+2
IUPAC name	zinc(2+)
Molecular weight	65.38
Hydrogen bond acceptor	0
Hydrogen bond donor	0
XlogP	None
Synonyms	CHEMBL1236970 Lamazym Native Canavalia ensiformis (Jack bean) a-Mannosidase Velmanase Alfa Zinc cation zinc(2+) ion Zn2+ AC1L1MW2 alpha-Mannosidase EINECS 232-794-1 Mannosidase, alpha, class 2b, member 1, recombinant Recombinant Human Alpha-mannosidase Zinc (2+) Zinc, ion (Zn2+) 13S1S8SF37 C00038 I14-114613 MCULE-6561885094 UNII-13S1S8SF37 Zinc (II) ion Zinc ions Zn++ 23713-49-7 alpha-Mannanase D04DWJ Lysosomal alpha-mannosidase, recombinant PTFCDOFLOPIGGS-UHFFFAOYSA-N Velmanase Alfa [INN] Zinc dication Zinc(2+)ions alpha-Mannosidase recombinant human FT-0622172 Mannosidase, alpha- Recombinant human laman Zinc (II) Zinc ion (2+) Zn(2+) 1492823-75-2 CHEBI:29105 I14-114614 Microheterogeneityzinc Ion UNII-M91TG242P2 Zinc 2+ zinc(2+) Zn+2 9025-42-7 alpha-Mannopyranosidase dietary zinc M91TG242P2 R-H-Laman Velmanase alfa [WHO-DD] Zinc divalent ion zinc(II) cation BDBM16 I14-114612 Mannosidase, alpha- (synthetic human) Rhlaman Zinc (II) cation ZINC ION ON 3-FOLD CRYSTAL AXIS Zn(II) [ Show all ]
Inchi Key	PTFCDOFLOPIGGS-UHFFFAOYSA-N
Inchi ID	InChI=1S/Zn/q+2
PubChem CID	32051
ChEMBL	N/A
IUPHAR	N/A
BindingDB	16
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3.6 nM	PMID25313322	BindingDB

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