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GPCR

Name	Beta-2 adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRB2
Synonym	beta-2 adrenergic receptor Gpcr7 beta2-adrenoceptor Adrb-2 ADRB2R ADRBR adrenergic receptor adrenoceptor beta 2, surface beta-2 adrenoreceptor Beta-2 adrenoceptor B2AR beta 2-AR [ Show all ]
Disease	Premature labour Premature ejaculation Obesity Neurogenic bladder dysfunction Hypertension Ocular hypertension Chronic obstructive pulmonary disease; Asthma Chronic obstructive pulmonary disease Chronic breathing disorders Cachexia Bronchodilator Bradycardia; Heart block Skin infections Unspecified Acute asthma Aging skin; Exacerbations of acute asthma Asthma; Chronic obstructive pulmonary disease Asthma [ Show all ]
Length	413
Amino acid sequence	MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
UniProt	P07550
Protein Data Bank	3nya, 3ny9, 3ny8, 3d4s, 2rh1, 3pds, 4gbr, 4lde, 6mxt, 6csy, 5x7d, 5jqh, 5d6l, 5d5b, 5d5a, 4ldo, 4ldl, 4qkx
GPCR-HGmod model	P07550
3D structure model	This structure is from PDB ID 3nya.
BioLiP	BL0257082, BL0113951, BL0113950, BL0257084, BL0257085, BL0283869, BL0333729, BL0333730, BL0333731,BL0333732,BL0333733, BL0333734, BL0333735, BL0333736,BL0333737,BL0333738, BL0113952,BL0113953,BL0113954, BL0147310, BL0257081, BL0257080, BL0232997, BL0192129, BL0257083, BL0185746,BL0185747, BL0185745, BL0185743,BL0185744, BL0185742, BL0185740,BL0185741, BL0147311,BL0147312, BL0351701,BL0351703, BL0351702,BL0351704, BL0192128, BL0433200, BL0433199, BL0430930, BL0430929, BL0388810, BL0388809, BL0354449, BL0185748, BL0354450, BL0354451,BL0354452,BL0354453, BL0388807,BL0388808
Therapeutic Target Database	T24555, T52522
ChEMBL	CHEMBL210
IUPHAR	29
DrugBank	BE0000694

Ligand

Name	AMPHETAMINE
Molecular formula	C9H13N
IUPAC name	1-phenylpropan-2-amine
Molecular weight	135.21
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	1.8
Synonyms	MCULE-4193952437 NSC 27159 Oraldrina (Salt/Mix) Phenethylamine, .alpha.-methyl- Propisamine Rhinalator Thyramine FT-0694835 KB-50276 Amphetamine, its salts, optical isomers, and salts of its optical isomers .alpha.-Methylphenethylamine, d-form Benzeneethanamine, (S)- 1-Phenyl-2-aminopropane beta-Aminopropylbenzene 3-phenylpropan-2-amine CHEBI:132233 3797-EP2305648A1 D07445 3797-EP2371814A1 DivK1c_000991 Adderal DTXSID4022600 alpha-methyl phenethylamine Amfetamina [Italian] (+-)-Benzedrine AMPHETAMINE (SEE ALSO: D-AMPHETAMINE (51-64-9) & AMPHETAMINE SULFATE (60-13-9)) (Phenylisopropyl)amine NINDS_000991 NSC27159 Percomon Phenethylamine, alpha-methyl- rac-(2R)-1-phenylpropan-2-amine Simpatina WLN: ZY1&1R Fenopromin HSDB 3287 L000864 Anorexide .beta.-Phenylisopropylamin Benzeneethanamine, .alpha.-methyl-, (.alpha.S)- 1-Phenyl-2-propylamine beta-Phenylisopropylamin 3797-EP2295439A1 CHEMBL405 3797-EP2308870A2 DEA No. 1100 60-15-1 dl-alpha-Methylphenethylamine Adipan EINECS 206-096-2 alpha-Methylbenzeneethaneamine (+)-.alpha.-Methylphenethylamine Amfetamine [INN:BAN] (.+/-.)-.alpha.-Methylphenethylamine Amphetamine mixture with Dextroamphetamine (S)-.alpha.-Phenylethylamine LS-1148 Norephedrine, deoxy- Oktedrin Phenedrine Phenethylamine, D-.alpha.-methyl- racemic-Desoxynor-ephedrine Sympamine [1-(3-Methoxyphenyl)-2-propyl]amine Finam Isomyn .alpha.-Methylbenzeneethaneamine Benzebar 1-Phenyl-2-amino-propan Benzeneethanamine, alpha-methyl-, (+-)- 2-Amino-1-phenylpropane C07514 3797-EP2298779A1 d-.alpha.-Methylphenethylamine 3797-EP2311803A1 Desoxynorephedrine AC1Q5065 DL-Amphetamine solution, 1 mg/mL in methanol, drug standard AKOS022196414 Amfetamin (TN) (+-)-alpha-Methylphenethylamine Amphetamin (.+/-.)-Benzedrine Amphetamine Sulfate (2:1) Mecodrin NSC-27159 Ortedrine Phenethylamine, .alpha.-methyl-, (.+/-.)- Protioamphetamine SCHEMBL8858 Vapedrine (Salt/Mix) Fabedrine (Salt/Mix) GTPL4804 KBio1_000991 AN-23365 .alpha.-Methylphenylethylamine Benzeneethanamine, .alpha.-methyl- 1-Phenyl-2-aminopropane (VAN) beta-Aminopropylbenzene (VAN) 300-62-9 CHEBI:2679 3797-EP2305656A1 DL-.alpha.-Methylphenethylamine Adderall Dyanavel XR ALPHA-METHYL-BENZENEETHANAMIDE (SEE ALSO DL-AMPHETAMINE SULFATE) Amfetamine (+/-)-Amphetamine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material Amphetamine (tamper and abuse-resistant, Bio-MD/MPAR, ADHD) (plusmn)-amphetamine Noclon (Salt/Mix) NSC73713 PF-08 (Bio-MD/MPAR/prodrug/oral, ADHD), PharmacoFore Phenethylamine, alpha-methyl-, (+-)- rac-Amphetamine Stimulan (Salt/Mix) WLN: ZY1&1R -D Fenylo-izopropylaminyl IDI1_000991 levo-Amphetamine Anorexine .beta.-Phenylisopropylamine Benzeneethanamine, .alpha.-methyl-, (S)- 1-phenylpropan-2-amine beta-Phenylisopropylamin [German] 3797-EP2298734A2 component of Amodex 3797-EP2311801A1 DELCOBESE 96332-84-2 dl-Amphetamine Adzenys ER Elastonon alpha-Methylphenethylamine (+)-.alpha.-Methylphenylethylamine amfetaminum (.+/-.)-.alpha.-Methylphenylethylamine Amphetamine resin complex LS-1428 Novydrine Oprea1_447423 Phenethylamine, (+)- Profamina Raphetamine Sympatedrine FT-0631912 KB-219221 .alpha.-Methylphenethylamine Benzedrine 1-Phenyl-2-amino-propan [German] Benzolone 3-Phenyl-2-propylamine C9H13N 3797-EP2305219A1 D05BMG 3797-EP2314571A2 DEXTROAMP SACCHARATE, AMP ASPARTATE, DEXTROAMP SULFATE AND AMP SULFATE Actedron dl-Benzedrine Allodene Amfetamina [INN-Spanish] (+-)-alpha-Methylphenylethylamine (.+/-.)-Desoxynorephedrine AMPHETAMINE, (D) Mydrial NSC-73713 Ortenal (Salt/Mix) Phenethylamine, alpha-methyl, (+-)- Psychedrine Simpatedrin Weckamine Fenamin (Salt/Mix) HMS503G03 KWTSXDURSIMDCE-UHFFFAOYSA-N Anfetamina [Spanish] .beta.-Aminopropylbenzene Benzeneethanamine, .alpha.-methyl-, (.+/-.)- 1-Phenyl-2-propanamine beta-phenyl-isopropylamine 3797-EP2275420A1 3797-EP2308867A2 DB00182 60-13-9 (sulfate (2:1)) dl-1-Phenyl-2-aminopropane Adderall XR EINECS 200-458-3 alpha-Methylbenzeneethanamine Amfetamine (INN) (+/-)-Amphetamine solution, 100 mug/mL in methanol, ampule of 1 mL, certified reference material Amphetamine (tamper and abuse-resistant, Bio-MD/MPAR, ADHD), PharmacoFore (S)-(+)-.beta.-Phenylisopropylamine Levoamphetamine Norephedrane NT-0201 Phenamine Phenethylamine, d- rac-Amphetamine 1.0 mg/ml in Methanol Sympametin (Salt/Mix) Zedrine (Salt/Mix) Fenylo-izopropylaminyl [Polish] Isoamyne .alpha.-Methylbenzeneethanamine BDBM50005246 1-Methyl-2-phenylethylamine Benzeneethanamine, alpha-methyl- 17108-96-2 beta-Phenylisopropylamine 3797-EP2298742A1 component of Biphetamine 3797-EP2311802A1 Desoxynorephedrin AC1L1EYQ DL-Amphetamine solution AI3-02438 Euphodyn (Salt/Mix) alpha-Methylphenylethylamine (+-)-alpha-Methylbenzeneethanamine Amfetaminum [INN-Latin] (.+/-.)-.beta.-Phenylisopropylamine Amphetamine salts [ Show all ]
Inchi Key	KWTSXDURSIMDCE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3
PubChem CID	3007
ChEMBL	CHEMBL405
IUPHAR	N/A
BindingDB	50005246
DrugBank	DB00182
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID8699	BindingDB

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