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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Rattus norvegicus (Rat)
Gene	Chrm4
Synonym	cholinergic receptor cholinergic receptor, muscarinic 4 Chrm-4 HM3 M4 receptor
Disease	N/A for non-human GPCRs
Length	478
Amino acid sequence	MXNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProt	P08485
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL317
IUPHAR	16
DrugBank	N/A

Ligand

Name	VU0152117
Molecular formula	C22H28N4O3S
IUPAC name	3-amino-6-[3-(dimethylamino)propoxy]-N-[(4-methoxyphenyl)methyl]-4-methylthieno[2,3-b]pyridine-2-carboxamide
Molecular weight	428.551
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	4.2
Synonyms	BDBM48057 3-amino-6-[3-(dimethylamino)propoxy]-4-methyl-N-p-anisyl-thieno[2,3-b]pyridine-2-carboxamide 3-azanyl-6-[3-(dimethylamino)propoxy]-N-[(4-methoxyphenyl)methyl]-4-methyl-thieno[2,3-b]pyridine-2-carboxamide cid_45142469 3-amino-6-[3-(dimethylamino)propoxy]-N-[(4-methoxyphenyl)methyl]-4-methyl-2-thieno[2,3-b]pyridinecarboxamide 3-amino-6-[3-(dimethylamino)propoxy]-N-[(4-methoxyphenyl)methyl]-4-methylthieno[2,3-b]pyridine-2-carboxamide [ Show all ]
Inchi Key	JOVNETVRCHVSAD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H28N4O3S/c1-14-12-17(29-11-5-10-26(2)3)25-22-18(14)19(23)20(30-22)21(27)24-13-15-6-8-16(28-4)9-7-15/h6-9,12H,5,10-11,13,23H2,1-4H3,(H,24,27)
PubChem CID	45142469
ChEMBL	N/A
IUPHAR	N/A
BindingDB	48057
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	10000.0 nM	N/A	BindingDB

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