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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Rattus norvegicus (Rat)
Gene	Chrm4
Synonym	cholinergic receptor cholinergic receptor, muscarinic 4 Chrm-4 HM3 M4 receptor
Disease	N/A for non-human GPCRs
Length	478
Amino acid sequence	MXNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProt	P08485
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL317
IUPHAR	16
DrugBank	N/A

Ligand

Name	VU0402476-1
Molecular formula	C16H16N4OS
IUPAC name	3-amino-4,6-dimethyl-N-(pyridin-3-ylmethyl)thieno[2,3-b]pyridine-2-carboxamide
Molecular weight	312.391
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.9
Synonyms	cid_20417337 3-amino-4,6-dimethyl-N-(pyridin-3-ylmethyl)thieno[2,3-b]pyridine-2-carboxamide AKOS003682692 3-amino-4,6-dimethyl-N-(3-pyridinylmethyl)-2-thieno[2,3-b]pyridinecarboxamide Oprea1_764816 3-azanyl-4,6-dimethyl-N-(pyridin-3-ylmethyl)thieno[2,3-b]pyridine-2-carboxamide BDBM48050 3-amino-4,6-dimethyl-N-(3-pyridylmethyl)thieno[2,3-b]pyridine-2-carboxamide [ Show all ]
Inchi Key	IWDLUECGHJENQL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H16N4OS/c1-9-6-10(2)20-16-12(9)13(17)14(22-16)15(21)19-8-11-4-3-5-18-7-11/h3-7H,8,17H2,1-2H3,(H,19,21)
PubChem CID	20417337
ChEMBL	N/A
IUPHAR	N/A
BindingDB	48050
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.00559 nM	N/A	BindingDB

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