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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Rattus norvegicus (Rat)
Gene	Chrm4
Synonym	cholinergic receptor cholinergic receptor, muscarinic 4 Chrm-4 HM3 M4 receptor
Disease	N/A for non-human GPCRs
Length	478
Amino acid sequence	MXNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProt	P08485
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL317
IUPHAR	16
DrugBank	N/A

Ligand

Name	VU0402481-1
Molecular formula	C17H15F2N3OS
IUPAC name	3-amino-N-[(2,5-difluorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
Molecular weight	347.384
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	4.1
Synonyms	cid_44176132 3-amino-N-[(2,5-difluorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide BDBM48054 3-amino-N-(2,5-difluorobenzyl)-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide N-(2,5-Difluorobenzyl)-3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 3-azanyl-N-[[2,5-bis(fluoranyl)phenyl]methyl]-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide CHEMBL3040593 3-amino-N-[(2,5-difluorophenyl)methyl]-4,6-dimethyl-2-thieno[2,3-b]pyridinecarboxamide [ Show all ]
Inchi Key	DOMRFXCFPRIYBL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H15F2N3OS/c1-8-5-9(2)22-17-13(8)14(20)15(24-17)16(23)21-7-10-6-11(18)3-4-12(10)19/h3-6H,7,20H2,1-2H3,(H,21,23)
PubChem CID	44176132
ChEMBL	N/A
IUPHAR	N/A
BindingDB	48054
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.001 nM	N/A	BindingDB

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