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GPCR

Name	Histamine H1 receptor
Species	Homo sapiens (Human)
Gene	HRH1
Synonym	HH1R H1R Hisr H1 receptor
Disease	Vertigo's disease; Meniere's disease Ocular allergy Obesity Nausea; Vomiting Insomnia; Anxiety disorder Insomnia Hypersensitivity reactions; Coughs; Common colds Pain Parkinson's disease Perennial and seasonal allergic rhinitis; Vasomotor rhinitis; Allergic conjunctivitis Vertigo meniere's disease Unspecified Sleep disorders Seasonal and perennial allergic rhinitis and vasomotor rhinitis Rhinitis; Urticaria; Allergy Rhinitis Respiratory disease Respiratory allergies; Cancer Respiratory allergies; Allergic rhinitis Pruritus Nasal congestion Hay fever; Cough Hay fever; Allergic rhinitis Anxiety disorder Anesthesia Allergy Allergic skin disorders Allergic rhinitis; Urticaria; Pruritus Allergic rhinitis; Urticaria Allergic rhinitis Allergic disorders; Itching; Nausea Allergic conjunctivitis Anxiety disorder; Morning sickness Asthma Hay fever Common cold; Allergies Depression Dry cough [ Show all ]
Length	487
Amino acid sequence	MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
UniProt	P35367
Protein Data Bank	3rze
GPCR-HGmod model	P35367
3D structure model	This structure is from PDB ID 3rze.
BioLiP	BL0202178, BL0202179, BL0202180
Therapeutic Target Database	T77913
ChEMBL	CHEMBL231
IUPHAR	262
DrugBank	BE0000442

Ligand

Name	Metopimazine
Molecular formula	C22H27N3O3S2
IUPAC name	1-[3-(2-methylsulfonylphenothiazin-10-yl)propyl]piperidine-4-carboxamide
Molecular weight	445.596
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.1
Synonyms	1-[3-(2-methylsulfonylphenothiazin-10-yl)propyl]piperidine-4-carboxamide 14008-44-7 4-Piperidinecarboxamide, 1-[3-[2-(methylsulfonyl)-10H-phenothiazin-10-yl]propyl]- BDBM82383 CTK8E9457 J-007351 Metopimazinum TX-013443 1-[3-[2-(Methylsulfonyl)phenothiazin-10-yl]propyl]isonipecotamide 2-Methylsulfonyl-10-(3-(4-carbamoylpiperidino)propyl)phenothiazine AC1L1B19 C22H27N3O3S2 EINECS 237-818-4 Metopimazina [INN-Spanish] NSC_26388 Vogalene 1-(3-(2-(Methylsulfonyl)-10H-phenothiazin-10-yl)propyl)-4-piperidinecarboxamide 1-(3-(2-methylsulfonylphenothiazin-10-yl) propyl)isonipecotinamide 118285-EP2298764A1 4-Piperidinecarboxamide, 1-(3-(2-(methanesulfonyl)phenothiazin-10-yl)propyl)- BCP9000921 FT-0672379 Metopimazine [USAN:BAN:INN] RP-9965 1-[3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-4-piperidinecarboxamide 14170-03-7 4-Piperidinecarboxamide,1-[3-[2-(methylsulfonyl)-10H-phenothiazin-10-yl]propyl]- BQDBKDMTIJBJLA-UHFFFAOYSA-N D05010 LS-85054 Metopimazinum [INN-Latin] UNII-238S75V9AV 10-(3-(4-Carbamoylpiperidine)propyl)-2-(methanesulfonyl)phenothiazine 2-Methylsulfonyl-10-[3-(4-carbamoylpiperidino)propyl]phenothiazine AKOS005065914 CAS_26388 EXP 999 Phenothiazine, 10-(3-(4'-carbamoylpiperidino)propyl)-2-methylsulfonyl- ZINC537996 1-(3-(2-(Methylsulfonyl)phenothiazin-10-yl)propyl)-4-piperidinecarboxamide 1-(3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl)-4-piperidinecarboxamide # 118285-EP2298765A1 4-Piperidinecarboxamide, 1-(3-(2-(methylsulfonyl)-10H-phenothiazin-10-yl)propyl)- BDBM179867 CHEMBL398615 ISONIPECOTAMIDE, 1-(3-(2-(METHYLSULFONYL)PHENOTHIAZIN-10-YL)PROPYL)- Metopimazine [USAN:INN:BAN] SCHEMBL49905 1-[3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl]piperidin-4-carboxamide BRN 4278585 DTXSID80161224 Metopimazina Nortrip US9132134, Metopimazine (NG101) 1-(3-(2-(Methylsulfonyl)phenothiazin-10-yl)propyl)isonipecotamide 118285-EP2275420A1 238S75V9AV AN-17207 CHEBI:135726 EXP-999 Metopimazine (USAN/INN) RP 9965 [ Show all ]
Inchi Key	BQDBKDMTIJBJLA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H27N3O3S2/c1-30(27,28)17-7-8-21-19(15-17)25(18-5-2-3-6-20(18)29-21)12-4-11-24-13-9-16(10-14-24)22(23)26/h2-3,5-8,15-16H,4,9-14H2,1H3,(H2,23,26)
PubChem CID	26388
ChEMBL	CHEMBL398615
IUPHAR	N/A
BindingDB	179867, 82383
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	8.4 nM	, None	BindingDB,ChEMBL

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