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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H3 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH3
Synonym	H3R HH3R
Disease	N/A for non-human GPCRs
Length	445
Amino acid sequence	MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
UniProt	Q9JI35
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5076
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL88048
Molecular formula	C20H18N4O3S2
IUPAC name	[4-[2-[2-(1H-imidazol-5-yl)ethylsulfanyl]-1H-imidazol-5-yl]phenyl] benzenesulfonate
Molecular weight	426.509
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	3.8
Synonyms	Benzenesulfonic acid 4-[2-[2-(1H-imidazole-4-yl)ethylthio]-1H-imidazole-5-yl]phenyl ester BDBM50408179
Inchi Key	CMUOXPNQSSULRS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H18N4O3S2/c25-29(26,18-4-2-1-3-5-18)27-17-8-6-15(7-9-17)19-13-22-20(24-19)28-11-10-16-12-21-14-23-16/h1-9,12-14H,10-11H2,(H,21,23)(H,22,24)
PubChem CID	23277107
ChEMBL	CHEMBL88048
IUPHAR	N/A
BindingDB	50408179
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	50.12 nM	PMID9258364	BindingDB,ChEMBL

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