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Name | Somatostatin receptor type 3 |
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Species | Mus musculus (Mouse) |
Gene | Sstr3 |
Synonym | SSR-28 SS3R SS3-R SS-3-R SRIF1C [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 428 |
Amino acid sequence | MATVTYPSSEPTTLDPGNASSTWPLDTTLGNTSAGASLTGLAVSGILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTTRRVRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRIRSQEPGSGPPEKTEEEEDEEEEERREEEERRMQRGQEMNGRLSQIAQAGTSGQQPRPCTGTAKEQQLLPQEATAGDKASTLSHL |
UniProt | P30935 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2238 |
IUPHAR | 357 |
DrugBank | N/A |
Name | CHEMBL3323084 |
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Molecular formula | C30H24FN7O2 |
IUPAC name | 5-[(1R,3R)-3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]-1-(1-methylpyrazol-4-yl)-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]pyridine-3-carboxylic acid |
Molecular weight | 533.567 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 4 |
XlogP | 0.6 |
Synonyms | BDBM50053739 |
Inchi Key | SWKJCRBTZSASTH-FYBSXPHGSA-N |
Inchi ID | InChI=1S/C30H24FN7O2/c1-38-16-20(14-34-38)30(19-10-18(29(39)40)12-32-13-19)27-23(22-4-2-3-5-24(22)35-27)11-25(37-30)28-33-15-26(36-28)17-6-8-21(31)9-7-17/h2-10,12-16,25,35,37H,11H2,1H3,(H,33,36)(H,39,40)/t25-,30-/m1/s1 |
PubChem CID | 118710534 |
ChEMBL | CHEMBL3323084 |
IUPHAR | N/A |
BindingDB | 50053739 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 0.16 nM | PMID25050159 | BindingDB |
IC50 | 0.16 nM | PMID25050159 | ChEMBL |
Inhibition | 67.0 % | PMID25050159 | ChEMBL |
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