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GPCR

NameSomatostatin receptor type 3
SpeciesMus musculus (Mouse)
GeneSstr3
SynonymSSR-28
SS3R
SS3-R
SS-3-R
SRIF1C
[ Show all ]
DiseaseN/A for non-human GPCRs
Length428
Amino acid sequenceMATVTYPSSEPTTLDPGNASSTWPLDTTLGNTSAGASLTGLAVSGILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTTRRVRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRIRSQEPGSGPPEKTEEEEDEEEEERREEEERRMQRGQEMNGRLSQIAQAGTSGQQPRPCTGTAKEQQLLPQEATAGDKASTLSHL
UniProtP30935
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2238
IUPHAR357
DrugBankN/A

Ligand

NameCHEMBL3323084
Molecular formulaC30H24FN7O2
IUPAC name5-[(1R,3R)-3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]-1-(1-methylpyrazol-4-yl)-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]pyridine-3-carboxylic acid
Molecular weight533.567
Hydrogen bond acceptor7
Hydrogen bond donor4
XlogP0.6
SynonymsBDBM50053739
Inchi KeySWKJCRBTZSASTH-FYBSXPHGSA-N
Inchi IDInChI=1S/C30H24FN7O2/c1-38-16-20(14-34-38)30(19-10-18(29(39)40)12-32-13-19)27-23(22-4-2-3-5-24(22)35-27)11-25(37-30)28-33-15-26(36-28)17-6-8-21(31)9-7-17/h2-10,12-16,25,35,37H,11H2,1H3,(H,33,36)(H,39,40)/t25-,30-/m1/s1
PubChem CID118710534
ChEMBLCHEMBL3323084
IUPHARN/A
BindingDB50053739
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC500.16 nMPMID25050159BindingDB
IC500.16 nMPMID25050159ChEMBL
Inhibition67.0 %PMID25050159ChEMBL

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