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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Somatostatin receptor type 3
Species	Homo sapiens (Human)
Gene	SSTR3
Synonym	SSR-28 SS3R SS3-R SS-3-R SRIF1C somatostatin receptor 28 SST3 receptor [ Show all ]
Disease	N/A
Length	418
Amino acid sequence	MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL
UniProt	P32745
Protein Data Bank	N/A
GPCR-HGmod model	P32745
3D structure model	This predicted structure model is from GPCR-EXP P32745.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2028
IUPHAR	357
DrugBank	BE0003529

Ligand

Name	CHEMBL3323081
Molecular formula	C30H24FN7O2
IUPAC name	6-[(1S,3R)-3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]-1-(1-methylpyrazol-4-yl)-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]pyridine-2-carboxylic acid
Molecular weight	533.567
Hydrogen bond acceptor	7
Hydrogen bond donor	4
XlogP	1.0
Synonyms	BDBM50054509
Inchi Key	SJPXJRVMKATQCT-AYWVHJORSA-N
Inchi ID	InChI=1S/C30H24FN7O2/c1-38-16-18(14-33-38)30(26-8-4-7-23(34-26)29(39)40)27-21(20-5-2-3-6-22(20)35-27)13-24(37-30)28-32-15-25(36-28)17-9-11-19(31)12-10-17/h2-12,14-16,24,35,37H,13H2,1H3,(H,32,36)(H,39,40)/t24-,30-/m1/s1
PubChem CID	118710532
ChEMBL	CHEMBL3323081
IUPHAR	N/A
BindingDB	50054509
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	74.7 nM	PMID25050159	ChEMBL
IC50	75.0 nM	PMID25050159	BindingDB
IC50	105.0 nM	PMID25050159	BindingDB,ChEMBL
Inhibition	83.0 %	PMID25050159	ChEMBL

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