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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3354774
Molecular formula	C26H24F3N3O2
IUPAC name	ethyl (2R)-2-methyl-2-[6-methyl-3-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]-3-phenylpropanoate
Molecular weight	467.492
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	5.7
Synonyms	BDBM50036636 SCHEMBL1245002
Inchi Key	KWIOPQKUZLWYEN-RUZDIDTESA-N
Inchi ID	InChI=1S/C26H24F3N3O2/c1-4-34-24(33)25(3,14-18-8-6-5-7-9-18)22-17(2)15-30-23-21(16-31-32(22)23)19-10-12-20(13-11-19)26(27,28)29/h5-13,15-16H,4,14H2,1-3H3/t25-/m1/s1
PubChem CID	49855246
ChEMBL	CHEMBL3354774
IUPHAR	N/A
BindingDB	50036636
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1.0 nM	PMID25455488	ChEMBL
EC50	1.0 nM	PMID25455488	BindingDB
Efficacy	80.0 %	PMID25455488	ChEMBL

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