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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 39
Species	Homo sapiens (Human)
Gene	GPR39
Synonym	GPR39
Disease	Diabetes
Length	453
Amino acid sequence	MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEV
UniProt	O43194
Protein Data Bank	N/A
GPCR-HGmod model	O43194
3D structure model	This predicted structure model is from GPCR-EXP O43194.
BioLiP	N/A
Therapeutic Target Database	T88531
ChEMBL	CHEMBL3091266
IUPHAR	105
DrugBank	N/A

Ligand

Name	Zinkchlorid
Molecular formula	Cl2Zn
IUPAC name	zinc;dichloride
Molecular weight	136.28
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	None
Synonyms	ACMC-1BIC4 Cl2Zn Galvanizers Flux SC-54095 Zinc Chloride Solution 50% zinc-chloride CHEBI:49976 CTK2H7579 KSC377K7T TR-024482 ZINC CHLORIDE, U.S.P. AB1002914 Chlorure de zinc Epitope ID:156810 RP20302 Zinc Chloride (ca. 6.5% in Ethyl Ether, ca. 0.4mol/L) zinc(II)chloride AKOS024438088 Cloreto de zinco JIAARYAFYJHUJI-UHFFFAOYSA-L Sinkkikloridi ZINC CHLORIDE, ACS zincchloride D05ELV MolPort-003-925-261 TRA-0188177 zinc(2+) chloride Zinkklorid AC1MHN2P Chlorure de zinc anhydre FLUX LOTOP RTR-024482 Zinc Chloride 0.5M solution in Tetrahydrofuran zinc, ion (zn2+) dichloride ANW-41104 Cloruro de cinc KS-00000UXI Sinkklorio Zinc chloride, anhydrous zink chloride CHEMBL1200679 Dichlorek cynku (Chlorek cynku) R999 zinc (II) chloride zinc(II)-chloride ZnCl2 [ Show all ]
Inchi Key	JIAARYAFYJHUJI-UHFFFAOYSA-L
Inchi ID	InChI=1S/2ClH.Zn/h2*1H;/q;;+2/p-2
PubChem CID	3007855
ChEMBL	CHEMBL1200679
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3.6 nM	PMID25313322	ChEMBL
Efficacy	48.0 %	PMID25313322	ChEMBL

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