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GLASS

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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	MLS001034823
Molecular formula	C18H25ClN2O3S
IUPAC name	[3-(azepan-1-ylsulfonyl)-4-chlorophenyl]-piperidin-1-ylmethanone
Molecular weight	384.919
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.2
Synonyms	AC1O5TM4 ZINC6697586 HMS2983N21 [3-(azepan-1-ylsulfonyl)-4-chloro-phenyl]-piperidino-methanone MolPort-002-105-303 AKOS000918252 CHEMBL1543278 [3-(1-azepanylsulfonyl)-4-chlorophenyl]-(1-piperidinyl)methanone MCULE-1336729813 [3-(azepan-1-ylsulfonyl)-4-chlorophenyl]-piperidin-1-ylmethanone SMR000670877 BDBM62159 cid_6463414 [3-(azepan-1-ylsulfonyl)-4-chloranyl-phenyl]-piperidin-1-yl-methanone [ Show all ]
Inchi Key	CLHKLNZUACLMFZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H25ClN2O3S/c19-16-9-8-15(18(22)20-10-4-3-5-11-20)14-17(16)25(23,24)21-12-6-1-2-7-13-21/h8-9,14H,1-7,10-13H2
PubChem CID	6463414
ChEMBL	CHEMBL1543278
IUPHAR	N/A
BindingDB	62159
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	32659.0 nM	PubChem BioAssay data set	ChEMBL

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