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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	CHEMBL1939011
Molecular formula	C10H10N2O4
IUPAC name	5-ethyl-2-methoxy-3H-pyrano[2,3-d]pyrimidine-4,7-dione
Molecular weight	222.2
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	0.2
Synonyms	SCHEMBL16316732 915208-52-5 4H-Pyrano[2,3-d]pyrimidine-4,7(3H)-dione, 5-ethyl-2-methoxy- BDBM50362594 SCHEMBL12560606
Inchi Key	CLDYMPKOSLUPCZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H10N2O4/c1-3-5-4-6(13)16-9-7(5)8(14)11-10(12-9)15-2/h4H,3H2,1-2H3,(H,11,12,14)
PubChem CID	57393654
ChEMBL	CHEMBL1939011
IUPHAR	N/A
BindingDB	50362594
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	125.0 nM	PMID22209457	BindingDB,ChEMBL

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