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Name | C-C chemokine receptor type 1 |
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Species | Mus musculus (Mouse) |
Gene | Ccr1 |
Synonym | MIP1aR MIP-1alphaR MIP-1alpha/RANTES MIP-1alpha-R macrophage inflammatory protein-1 alpha receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 355 |
Amino acid sequence | MEISDFTEAYPTTTEFDYGDSTPCQKTAVRAFGAGLLPPLYSLVFIIGVVGNVLVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDDWIFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPALYFFKAQWEFTHRTCSPHFPYKSLKQWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPSEKKVKAVRLIFAITLLFFLLWTPYNLSVFVSAFQDVLFTNQCEQSKQLDLAMQVTEVIAYTHCCVNPIIYVFVGERFWKYLRQLFQRHVAIPLAKWLPFLSVDQLERTSSISPSTGEHELSAGF |
UniProt | P51675 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3872 |
IUPHAR | N/A |
DrugBank | N/A |
Name | UNII-AKQ3X6FEH0 |
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Molecular formula | C23H36ClN3O4 |
IUPAC name | 1-[(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-3-(2-hydroxy-2-methylpropyl)urea |
Molecular weight | 454.008 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 4 |
XlogP | 2.8 |
Synonyms | 1202400-18-7 BDBM50056504 CHEMBL3334824 Urea, N-((1R)-1-(((4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethyl-1-piperidinyl)carbonyl)-2-methylpropyl)-N'-(2-hydroxy-2-methylpropyl)- BMS-817399 [ Show all ] |
Inchi Key | GTDPZONCGOCXOD-JPYJTQIMSA-N |
Inchi ID | InChI=1S/C23H36ClN3O4/c1-15(2)18(26-20(29)25-13-22(5,6)30)19(28)27-12-11-23(31,21(3,4)14-27)16-7-9-17(24)10-8-16/h7-10,15,18,30-31H,11-14H2,1-6H3,(H2,25,26,29)/t18-,23+/m1/s1 |
PubChem CID | 44537841 |
ChEMBL | CHEMBL3334824 |
IUPHAR | N/A |
BindingDB | 50056504 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <50000.0 nM | PMID25101488 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417