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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Relaxin-3 receptor 2
Species	Homo sapiens (Human)
Gene	RXFP4
Synonym	RXFP4 RLN3R2 RLN3 receptor 2 relaxin/insulin-like family peptide receptor 4 relaxin/insulin like family peptide receptor 4 Relaxin family peptide receptor 4 Insulin-like peptide INSL5 receptor INSL5 receptor GPCR142 G-protein coupled receptor GPCR142 G-protein coupled receptor 100 G protein-coupled receptor 100 RXFPR4 [ Show all ]
Disease	N/A
Length	374
Amino acid sequence	MPTLNTSASPPTFFWANASGGSVLSADDAPMPVKFLALRLMVALAYGLVGAIGLLGNLAVLWVLSNCARRAPGPPSDTFVFNLALADLGLALTLPFWAAESALDFHWPFGGALCKMVLTATVLNVYASIFLITALSVARYWVVAMAAGPGTHLSLFWARIATLAVWAAAALVTVPTAVFGVEGEVCGVRLCLLRFPSRYWLGAYQLQRVVLAFMVPLGVITTSYLLLLAFLQRRQRRRQDSRVVARSVRILVASFFLCWFPNHVVTLWGVLVKFDLVPWNSTFYTIQTYVFPVTTCLAHSNSCLNPVLYCLLRREPRQALAGTFRDLRLRLWPQGGGWVQQVALKQVGRRWVASNPRESRPSTLLTNLDRGTPG
UniProt	Q8TDU9
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDU9
3D structure model	This predicted structure model is from GPCR-EXP Q8TDU9.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1628473
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	GSK137647A
Molecular formula	C16H19NO3S
IUPAC name	4-methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
Molecular weight	305.392
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.5
Synonyms	MolPort-000-626-674 SR-01000478738 349085-82-1 AOB2991 J-690285 NCGC00387253-02 STK899558 BCP17136 EU-0076636 MCULE-5583867808 SCHEMBL19357604 AK240703 CB15818 GSK 137647 N-mesityl-4-methoxy-1-benzenesulfonamide SR-01000478738-1 4-methoxy-N-(2,4,6-trimethylphenyl)benzene-1-sulfonamide AS-16737 CHEMBL3311308 GSK137647A, >=98% (HPLC) KB-3356964 Oprea1_349531 ZINC184126 AC1LEYMC BDBM50044849 EX-A1097 MFCD02007969 SMSF0014079 AKOS003261220 CBMicro_012617 GSK-137647A N-mesityl-4-methoxybenzenesulfonamide ST50719559 4-methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide B7793 CS-5549 HY-19995 KS-00000TIW Oprea1_545891 [(4-methoxyphenyl)sulfonyl](2,4,6-trimethylphenyl)amine AJ-292/14925630 BIM-0012523.P001 FT-0700296 [ Show all ]
Inchi Key	FQUAFMNPXPXOJE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H19NO3S/c1-11-9-12(2)16(13(3)10-11)17-21(18,19)15-7-5-14(20-4)6-8-15/h5-10,17H,1-4H3
PubChem CID	743974
ChEMBL	CHEMBL3311308
IUPHAR	N/A
BindingDB	50044849
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<50118.7 nM	PMID24881566	ChEMBL
EC50	>50119.0 nM	PMID24881566	BindingDB

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