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GPCR

NameFree fatty acid receptor 2
SpeciesHomo sapiens (Human)
GeneFFAR2
SynonymFFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
GPR43
[ Show all ]
DiseaseAbortion
Diabetes
Length330
Amino acid sequenceMLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProtO15552
Protein Data BankN/A
GPCR-HGmod modelO15552
3D structure modelThis predicted structure model is from GPCR-EXP O15552.
BioLiPN/A
Therapeutic Target DatabaseT28213
ChEMBLCHEMBL5493
IUPHAR226
DrugBankN/A

Ligand

NameCHEMBL3353506
Molecular formulaC23H23ClN4O4
IUPAC name2-[[1-[2-(benzimidazol-1-yl)acetyl]-2-methylazetidine-2-carbonyl]-[(4-chlorophenyl)methyl]amino]acetic acid
Molecular weight454.911
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.7
SynonymsBDBM50032275
Inchi KeyDAKNKXBCXSIKLC-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H23ClN4O4/c1-23(22(32)26(14-21(30)31)12-16-6-8-17(24)9-7-16)10-11-28(23)20(29)13-27-15-25-18-4-2-3-5-19(18)27/h2-9,15H,10-14H2,1H3,(H,30,31)
PubChem CID118719621
ChEMBLCHEMBL3353506
IUPHARN/A
BindingDB50032275
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<10000.0 nMPMID25380412BindingDB,ChEMBL

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