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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	4-(Dimethylamino)cinnamic acid
Molecular formula	C11H13NO2
IUPAC name	(E)-3-[4-(dimethylamino)phenyl]prop-2-enoic acid
Molecular weight	191.23
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	1.9
Synonyms	MFCD00004397 p-(Dimethylamino)cinnamic acid ST24041448 (2E)-3-[4-(dimethylamino)phenyl]prop-2-enoic acid 3-[4-(Dimethylamino)phenyl]-2-propenoic acid # 4-(N,N-Dimethylamino)cinnamic acid AI3-62575 CQNPVMCASGWEHM-VMPITWQZSA-N NSC-13673 p-n,n-dimethylaminocinnamic acid TR-006490 (E)-3-[4-(dimethylamino)phenyl]acrylic acid 4-dimethylaminocinnamic acid AN-49429 GEO-01146 NSC638140 SBB063891 3-(4-(Dimethylamino)phenyl)acrylic acid 4-(N,N-Dimethamino)cinnamic acid AC1LTUVY KB-71648 MolPort-000-154-724 p-dimethylaminocinnamic acid ST45169471 (e)-3-(4-(dimethylamino)phenyl)acrylic acid 3-[4-(dimethylamino)phenyl]acrylic acid 4-(N-Dimethylamino)cinnamic acid AJ-26267 Dimethylaminocinnamic acid NSC-638140 PubChem8236 W-108022 (E)-3-[4-(dimethylamino)phenyl]prop-2-enoic acid 4-(Dimethylamino)cinnamic acid, 99% 5676-65-3 C-08272 I01-3219 M-2387 NSC643350 SC-42011 3-(p-(Dimethylamino)phenyl)acrylic acid 4-(n,n-dimethyamino)cinnamic acid AE-641/05563006 CHEMBL1771755 MolPort-011-018-597 p-Dimethylaminocinnamic acid, sodium salt SY015930 (E)-3-(4-dimethylaminophenyl)prop-2-enoic acid 3-[4-(dimethylamino)phenyl]prop-2-enoic acid 4-Dimethylamino cinnamic acid AKOS000263375 EINECS 216-299-8 NSC13673 RTR-006490 ZINC1471033 1552-96-1 4-(Dimethylamino)Cinnamic Acid. AB0008341 CC-16877 Jsp003040 [ Show all ]
Inchi Key	CQNPVMCASGWEHM-VMPITWQZSA-N
Inchi ID	InChI=1S/C11H13NO2/c1-12(2)10-6-3-9(4-7-10)5-8-11(13)14/h3-8H,1-2H3,(H,13,14)/b8-5+
PubChem CID	1540638
ChEMBL	CHEMBL1771755
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	0.0 %	PMID21167710	ChEMBL

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