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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Platelet-activating factor receptor
Species	Cavia porcellus (Guinea pig)
Gene	PTAFR
Synonym	PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	342
Amino acid sequence	MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProt	P21556
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5136
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL170398
Molecular formula	C28H25N5O5
IUPAC name	methyl 1-(dimethylcarbamoyl)-3-[4-[(2-methyl-4-oxo-5H-imidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]indole-4-carboxylate
Molecular weight	511.538
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.0
Synonyms	1-Dimethylcarbamoyl-3-[4-(2-methyl-4-oxo-4,5-dihydro-imidazo[4,5-c]pyridin-1-ylmethyl)-benzoyl]-1H-indole-4-carboxylic acid methyl ester BDBM50062119
Inchi Key	CJZRHJYAMUYAKM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H25N5O5/c1-16-30-24-22(12-13-29-26(24)35)32(16)14-17-8-10-18(11-9-17)25(34)20-15-33(28(37)31(2)3)21-7-5-6-19(23(20)21)27(36)38-4/h5-13,15H,14H2,1-4H3,(H,29,35)
PubChem CID	10815591
ChEMBL	CHEMBL170398
IUPHAR	N/A
BindingDB	50062119
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4.0 nM	PMID9438024	BindingDB,ChEMBL

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