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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Rattus norvegicus (Rat)
Gene	Htr7
Synonym	GPRFO 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 5-HTx 5-HT7 receptor 5-HT7 5-HT1Y 5-HT-X 5-HT-7 Serotonin receptor 7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	448
Amino acid sequence	MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProt	P32305
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3223
IUPHAR	12
DrugBank	N/A

Ligand

Name	5-Methoxy-N,N-dimethyltryptamine
Molecular formula	C13H18N2O
IUPAC name	2-(5-methoxy-1H-indol-3-yl)-N,N-dimethylethanamine
Molecular weight	218.3
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	1.5
Synonyms	Indole, 3-[2-(dimethylamino)ethyl]-5-methoxy- MeODMT 2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamine N,N-Dimethyl-5-methoxytryptamine, free base 3-(2-Dimethylaminoethyl)-5-methoxyindole; 3-[2-(Dimethylamino)ethyl]-5-methoxyindole; 5-MeO-DMT; 5-Methoxy-DMT; 5-OMe-DMT NCGC00023288-03 5-methoxy-3-N,N-dissopropylamino-ethylindole PDSP1_000447 5-OMe-DMT SDCCGMLS-0003129.P003 BC220661 ZINC57152 CHEBI:2086 DB-005455 HMS2235C20 I382 Lopac-M-2381 1019-45-0 Methylbufotenine 2-(5-Methoxy-1H-indol-3-yl)-N,N-dimethylethanamine # NCGC00015654-02 3-[2-(N,N-Dimethylamino)ethyl]-5-methoxyindole NSC-88624 5-Methoxy-N,N-dimethyl-1H-indole-3-ethylamine QC-3154 AC1L1CC9 STK368074 BRN 0164771 [2-(5-methoxy-1H-indol-3-yl)ethyl]dimethylamine cid_1832 EINECS 213-813-2 Indole, 3-(2-(dimethylamino)ethyl)-5-methoxy- (8CI) Maybridge3_000045 1H-Indole-3-ethanamine, 5-methoxy-N,N-dimethyl- (9CI) N,N-Dimethyl-5-methoxy tryptamine 3-(2-(N,N-Dimethylamino)ethyl)-5-methoxyindole NCGC00015654-05 5-MeO-DMT Oprea1_596468 5-Methoxydimethyltryptamine SBB003367 ANW-59888 WLN: T56 BMJ D2N1&1 GO1 C08309 D-5380 GTPL145 HMS3370M04 Indole,N-dimethylamino)ethyl]-5-methoxy- Methoxybufotenin 2-(5-methoxy-1H-indol-3-yl)-N,N-dimethylethan-1-amine N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N,N-dimethylamine 3-[2-(Dimethylamino)ethyl]-5-methoxyindole NCGC00023288-04 5-Methoxy-DMT PDSP2_000032 AB0013660 SMR000059066 BDBM30707 ZSTKHSQDNIGFLM-UHFFFAOYSA-N IDI1_011432 Lopac0_000724 MFCD00005658 2-(5-methoxy-1H-indol-3-yl)ethyl-dimethyl-amine NCGC00015654-03 NSC88624 RP05082 AKOS005203483 TL8000106 Bufotenine, 5-Methoxydimethyltryptamine [2-(5-methoxyindol-3-yl)ethyl]dimethylamine CT 4334 FT-0082567 INDOLE, 3-(2-(N,N-DIMETHYLAMINO)ETHYL)-5-METHOXY- MCULE-1161800007 2-(5-methoxy-1H-indol-3-yl)-ethyl-dimethyl-amine N,N-Dimethyl-5-methoxytryptamine 3-(2-Dimethylaminoethyl)-5-methoxyindole NCGC00015654-06 5-MeO-DMT solution, 1.0 mg/mL in methanol, certified reference material PDSP1_000032 5-methoxyindole 3-(2-(N,N-Dimethylamino)ethyl) SCHEMBL132733 API0007109 X0MKX3GWU9 CCG-204809 D0C5XQ HMS1431C01 I05-0003 L000724 019D450 Methoxydimethyltryptamines 2-(5-Methoxy-1H-indol-3-yl)-N,N-dimethylethanamine NCGC00015654-01 3-[2-(N,N-Dimethylamino)ethyl]-5-methoxy-indole NSC 88624 5-Methoxy-N,N-dimethyl-1H-indole-3-ethanamine PDSP2_000445 AB1007126 ST50308247 BRD-K34224286-001-07-1 [2-(5-METHOXY-1H-INDOL-3-YL)-ETHYL]-DIMETHYL-AMINE CHEMBL7257 DTXSID70144324 Indole, 3-(2-(dimethylamino)ethyl)-5-methoxy- LS-82935 1H-Indole-3-ethanamine, 5-methoxy-N,N-dimethyl- MLS000069438 3-(2-(N,N-Dimethyl)aminoethyl)-5-methoxyindole NCGC00015654-04 5-22-12-00027 (Beilstein Handbook Reference) O-Methylbufotenine 5-Methoxy-N,N-Dimethyltryptamine(5-MeO-DMT) RT-004787 AN-48328 UNII-X0MKX3GWU9 Bufotenine, O-methyl- CTK3J0837 FT-0601228 [ Show all ]
Inchi Key	ZSTKHSQDNIGFLM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H18N2O/c1-15(2)7-6-10-9-14-13-5-4-11(16-3)8-12(10)13/h4-5,8-9,14H,6-7H2,1-3H3
PubChem CID	1832
ChEMBL	CHEMBL7257
IUPHAR	145
BindingDB	30707
DrugBank	DB14010
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Increase	92.0 %	PMID14640545	ChEMBL
Ki	8.26 nM	PMID8394362	BindingDB
Ki	8.31 nM	PMID7984267	BindingDB
Ki	19.9526 - 39.8107 nM	PMID8394362	IUPHAR
Ki	20.89 nM	PMID7984267	BindingDB
Ki	20.9 nM	PMID8394362	BindingDB
Ki	39.81 nM	PMID14640545	ChEMBL

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