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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Type-2 angiotensin II receptor
Species	Rattus norvegicus (Rat)
Gene	Agtr2
Synonym	angiotensin II receptor, type 2 MRX88 Agtr2 AT2R AT2-R AT2 receptor angiotensin II receptor angiotensin receptor 2 Angiotensin II type-2 receptor angiotensin II type 2 receptor AT2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	363
Amino acid sequence	MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
UniProt	P35351
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL257
IUPHAR	35
DrugBank	N/A

Ligand

Name	CHEMBL132408
Molecular formula	C27H24N8O
IUPAC name	[5-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]indol-1-yl]-[2-(2H-tetrazol-5-yl)phenyl]methanone
Molecular weight	476.544
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.7
Synonyms	SCHEMBL9662040 AFOQZUNUKPCIHO-UHFFFAOYSA-N 3-[N-(2-tetrazol-5-yl-benzoyl)-5-indolyl]methyl-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine [5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-4-ylmethyl)-indol-1-yl]-[2-(1H-tetrazol-5-yl)-phenyl]-methanone BDBM50043436 L007654 [ Show all ]
Inchi Key	AFOQZUNUKPCIHO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H24N8O/c1-4-23-29-24-16(2)13-17(3)28-26(24)35(23)15-18-9-10-22-19(14-18)11-12-34(22)27(36)21-8-6-5-7-20(21)25-30-32-33-31-25/h5-14H,4,15H2,1-3H3,(H,30,31,32,33)
PubChem CID	10367704
ChEMBL	CHEMBL132408
IUPHAR	N/A
BindingDB	50043436
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	130.0 nM	PMID8277505	BindingDB,ChEMBL

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