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Name | Somatostatin receptor type 1 |
---|---|
Species | Homo sapiens (Human) |
Gene | SSTR1 |
Synonym | SRIF-2 SS-1-R SS1-R SS1R SST1 receptor |
Disease | Alzheimer disease Cushing's disease Neuroendocrine cancer |
Length | 391 |
Amino acid sequence | MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL |
UniProt | P30872 |
Protein Data Bank | N/A |
GPCR-HGmod model | P30872 |
3D structure model | This predicted structure model is from GPCR-EXP P30872. |
BioLiP | N/A |
Therapeutic Target Database | T16633 |
ChEMBL | CHEMBL1917 |
IUPHAR | 355 |
DrugBank | BE0000452 |
Name | BDBM84638 |
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Molecular formula | C58H71N11O10 |
IUPAC name | (2S)-6-amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-naphthalen-1-yl-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanamide |
Molecular weight | 1082.27 |
Hydrogen bond acceptor | 12 |
Hydrogen bond donor | 13 |
XlogP | 3.4 |
Synonyms | BIM 23070 |
Inchi Key | ZROMZGCPGMXTNI-RXIRDAQOSA-N |
Inchi ID | InChI=1S/C58H71N11O10/c1-33(63-54(75)44(60)28-36-14-5-4-6-15-36)53(74)67-48(29-37-23-25-41(71)26-24-37)56(77)68-49(31-40-32-62-45-21-10-9-20-43(40)45)57(78)65-46(22-11-12-27-59)55(76)69-50(35(3)70)58(79)64-34(2)52(73)66-47(51(61)72)30-39-18-13-17-38-16-7-8-19-42(38)39/h4-10,13-21,23-26,32-35,44,46-50,62,70-71H,11-12,22,27-31,59-60H2,1-3H3,(H2,61,72)(H,63,75)(H,64,79)(H,65,78)(H,66,73)(H,67,74)(H,68,77)(H,69,76)/t33-,34-,35?,44+,46-,47-,48-,49+,50-/m0/s1 |
PubChem CID | 91898904 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 84638 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 1000.0 nM | PMID8100350 | BindingDB |
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