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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	benzimidazole, 5
Molecular formula	C23H24N4O2
IUPAC name	(5-methoxy-1H-indol-2-yl)-[4-(2-methylbenzimidazol-1-yl)piperidin-1-yl]methanone
Molecular weight	388.471
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.9
Synonyms	1-{1-[(5-methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl}-2-methyl-1H-1,3-benzodiazole BDBM21696 CHEMBL404003 ZINC14976935 AKOS030284281
Inchi Key	CJFMJEUEUPHGHU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H24N4O2/c1-15-24-20-5-3-4-6-22(20)27(15)17-9-11-26(12-10-17)23(28)21-14-16-13-18(29-2)7-8-19(16)25-21/h3-8,13-14,17,25H,9-12H2,1-2H3
PubChem CID	24776345
ChEMBL	CHEMBL404003
IUPHAR	N/A
BindingDB	21696
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	PMID17920884	ChEMBL

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