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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Mus musculus (Mouse)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P12657
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3733
IUPHAR	13
DrugBank	N/A

Ligand

Name	CHEMBL538224
Molecular formula	C6H11N3O2
IUPAC name	methyl 2-amino-1,4,5,6-tetrahydropyrimidine-5-carboxylate
Molecular weight	157.173
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	-1.5
Synonyms	2-Amino-1,4,5,6-tetrahydro-5-pyrimidinecarboxylic acid methyl ester BDBM50039844 SCHEMBL8305945 2-Amino-1,4,5,6-tetrahydro-pyrimidine-5-carboxylic acid methyl ester; hydrochloride CHEMBL1189166
Inchi Key	ZLKLDBVBCKTENU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H11N3O2/c1-11-5(10)4-2-8-6(7)9-3-4/h4H,2-3H2,1H3,(H3,7,8,9)
PubChem CID	10441934
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50039844
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	160000.0 nM	PMID9111297	BindingDB

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