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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Mus musculus (Mouse)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P12657
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3733
IUPHAR	13
DrugBank	N/A

Ligand

Name	CHEMBL538224
Molecular formula	C6H11N3O2
IUPAC name	methyl 2-amino-1,4,5,6-tetrahydropyrimidine-5-carboxylate
Molecular weight	157.173
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	-1.5
Synonyms	2-Amino-1,4,5,6-tetrahydro-5-pyrimidinecarboxylic acid methyl ester BDBM50039844 SCHEMBL8305945 2-Amino-1,4,5,6-tetrahydro-pyrimidine-5-carboxylic acid methyl ester; hydrochloride CHEMBL1189166
Inchi Key	ZLKLDBVBCKTENU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H11N3O2/c1-11-5(10)4-2-8-6(7)9-3-4/h4H,2-3H2,1H3,(H3,7,8,9)
PubChem CID	10441934
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50039844
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	160000.0 nM	PMID9111297	BindingDB

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