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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	Adenosine triphosphate
Molecular formula	C10H16N5O13P3
IUPAC name	[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular weight	507.181
Hydrogen bond acceptor	17
Hydrogen bond donor	7
XlogP	-5.7
Synonyms	AJ-70571 ATP (nucleotide) 1259312-93-0 Bio1_000895 1m83 Cardenosine 1xsc D02LMZ 5'-(tetrahydrogen triphosphate) Adenosine DSSTox_RID_76629 8L70Q75FXE H4atp Adenosine 5 inverted exclamation marka-triphosphate (ATP) disodium salt hydrate SCHEMBL8979 Adenosine 5'-triphosphate (intravenous, paroxysmal supraventricular tachycardia (PSVT)), Duska Triphosphoric acid adenosine ester adenosine-triphosphate [[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid AN-41693 ATPase 1b38 bmse000854 1r0x CHEBI:15422 DB-022415 51569-41-6 Epitope ID:135612 9H-purin-6-amine, 9-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl] MolPort-002-533-479 Adenosine 5'-triphosphate Tox21_112044 Adenosine 5'-triphosphoric acid X5319 Adenylpyrophosphoric acid Atipi 065A467 BDBM50366480 1gz4 C00002 1vjc CS-7674 34369-07-8 DSSTox_CID_2559 84412-18-0 Glucobasin AC1L1LHX Phosphobion Adenosine 5'-triphosphate (intravenous, arrhythmia), Duska Triphosadenine (DCF) adenosine-5'-triphosphate [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate Ado-5'-P-P-P AK-54737 ATP disodium hydrate 16488-07-6 Bio1_001384 1mau CAS-56-65-5 1y8p D08646 5'-Atp DTXSID6022559 9-beta-D-Arabinofuranosyladenine 5'-triphosphate HY-B2176 adenosine 5' triphosphate ST24045923 Adenosine 5'-triphosphate; Triphosphaden UNII-8L70Q75FXE Adenosintriphosphorsaeure Ara-ATP ((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate Atriphos 1b39 bmse000993 1r10 2cbz 56-65-5 Fosfobion 9H-Purin-6-amine, 9-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-.beta.-D-ribofuranosyl]- Myotriphos Adenosine 5'-triphosphate (intravenous, arrhythmia) Triadenyl ZINC4261765 Adephos Adynol ATP 10168-83-9 Bio1_000406 1kxp C10H16N5O13P3 1vjd CTK3J3236 3h-adenosine triphosphate DSSTox_GSID_22559 896506-78-8 GTPL1713 ACT02649 RT-001349 Adenosine 5'-triphosphate (intravenous, bradycardia-induced syncopy (fainting)), Duska Triphosphaden adenosine-5'-triphosphoric acid [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate AKOS022179934 ATPace bmse000006 1maw CC-23792 1yid D0O6QI EINECS 200-283-2 917074-14-7 LS-15176 Adenosine 5'-(tetrahydrogen triphosphate) Striadyne Adenosine 5'-triphosphorate W-105506 Adenylpyrophosphorate AS-19204 ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid BDBM2 1gz3 C-22981 1t44 CHEMBL14249 2fgh DB00171 71800-44-7 FT-0621909 A9788C43-4BC5-46E2-8560-41C5FA7D3AA3 NCGC00163309-01 Adenosine 5'-triphosphate (intravenous, arrhythmia), Cordex Triphosaden Adenosine, 5'-(tetrahydrogen triphosphate) ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adetol [ Show all ]
Inchi Key	ZKHQWZAMYRWXGA-KQYNXXCUSA-N
Inchi ID	InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
PubChem CID	5957
ChEMBL	CHEMBL14249
IUPHAR	1713
BindingDB	2, 50366480
DrugBank	DB00171
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Potency	25118.9 nM	PubChem BioAssay data set	ChEMBL

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