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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Rattus norvegicus (Rat)
Gene	Hcar2
Synonym	Protein PUMA-G Nicotinic acid receptor Nic1 Niacr1 niacin receptor 1 HCA2 receptor G-protein coupled receptor HM74A G-protein coupled receptor HM74 G-protein coupled receptor 109A G-protein coupled receptor 109 G protein-coupled receptor 109A PUMAG [ Show all ]
Disease	N/A for non-human GPCRs
Length	360
Amino acid sequence	MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSICYTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVICFLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
UniProt	Q80Z39
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4731
IUPHAR	312
DrugBank	N/A

Ligand

Name	5-Butyl-1H-pyrazole-3-carboxylic acid
Molecular formula	C8H12N2O2
IUPAC name	5-butyl-1H-pyrazole-3-carboxylic acid
Molecular weight	168.196
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.8
Synonyms	AC1O5JK4 CHM0075795 MolPort-002-026-457 ZJTXSGLJNBAMJS-UHFFFAOYSA-N 3-butylpyrazole-5-carboxylic acid 5-Butyl-2H-pyrazole-3-carboxylic acid BAS 13299640 D0FF9F SCHEMBL1527555 890624-89-2 LUF6283, >=95% (HPLC) TR-044740 2213AF AKOS000301963 CTK6D6234 MolPort-027-640-734 ZX-AV000908 5-butyl-1H-pyrazol-3-carboxylic acid 5-n-butyl-1H-pyrazole-3-carboxylic acid BBL030719 F3250-0691 ST50210427 92933-48-7 CHEMBL428730 MCULE-3295355527 ZINC4386887 3-butyl-1H-pyrazole-5-carboxylic acid AKOS024458395 CTK8F6771 SBB027985 BDBM50220842 GTPL1591 STL257894 1H-Pyrazole-3-carboxylic acid, 5-butyl- [ Show all ]
Inchi Key	ZJTXSGLJNBAMJS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H12N2O2/c1-2-3-4-6-5-7(8(11)12)10-9-6/h5H,2-4H2,1H3,(H,9,10)(H,11,12)
PubChem CID	6485181
ChEMBL	CHEMBL428730
IUPHAR	1591
BindingDB	50220842
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	72.0 nM	PMID12930155	BindingDB,ChEMBL
Ki	79.4328 nM	PMID12930155	IUPHAR

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