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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Metabotropic glutamate receptor 6
Species	Rattus norvegicus (Rat)
Gene	Grm6
Synonym	nob3 nob2 nerg1 mGluR6 mGlu6 receptor Gprc1f glutamate receptor nob4 [ Show all ]
Disease	N/A for non-human GPCRs
Length	871
Amino acid sequence	MGRLPVLLLWLAWWLSQAGIACGAGSVRLAGGLTLGGLFPVHARGAAGRACGALKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEASVRCPGGVPPLRSAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFHKVIRRLMETPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSAYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEVLRWSGDPHEVPPSQCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAVLGIMATTTIMATFMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAICAARRLLLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKKTSTMAAPPQNENAEDAK
UniProt	P35349
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3842
IUPHAR	294
DrugBank	N/A

Ligand

Name	CHEMBL1089515
Molecular formula	C7H14NO6P
IUPAC name	(2S)-2-amino-4-[2-carboxyethyl(hydroxy)phosphoryl]butanoic acid
Molecular weight	239.164
Hydrogen bond acceptor	7
Hydrogen bond donor	4
XlogP	-4.8
Synonyms	BDBM50314793 (S)-2-Amino-4-[(2-carboxy-ethyl)-hydroxy-phosphinoyl]-butyric acid; dihydrochloride CHEMBL557573 AC1O40FI (2S)-2-amino-4-[2-carboxyethyl(hydroxy)phosphoryl]butanoic acid (S)-3-amino-3-carboxypropyl-2''-carboxyethyl phosphinic acid SCHEMBL4084993 BDBM50174524 (S)-2-Amino-4-(3-oxo-3-hydroxypropylhydroxyphosphinyl)butanoic acid [ Show all ]
Inchi Key	CIOKCIBFBZYLCA-YFKPBYRVSA-N
Inchi ID	InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
PubChem CID	6348408
ChEMBL	CHEMBL1089515
IUPHAR	N/A
BindingDB	50314793
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	6700.0 nM	PMID20218620	BindingDB,ChEMBL
EC50	31000.0 nM	PMID20218620	BindingDB,ChEMBL
EC50	32000.0 nM	PMID20218620	BindingDB

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