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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	N-arachidonyl glycine receptor
Species	Homo sapiens (Human)
Gene	GPR18
Synonym	GPCRW G-protein coupled receptor 18 N-arachidonoyol glycine receptor NAGly receptor GPR18
Disease	N/A
Length	331
Amino acid sequence	MITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCTTKKRTTVTIYMMNVALVDLIFIMTLPFRMFYYAKDEWPFGEYFCQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYKDPDKDSTPATCLKISDIIYLKAVNVLNLTRLTFFFLIPLFIMIGCYLVIIHNLLHGRTSKLKPKVKEKSIRIIITLLVQVLVCFMPFHICFAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEML
UniProt	Q14330
Protein Data Bank	N/A
GPCR-HGmod model	Q14330
3D structure model	This predicted structure model is from GPCR-EXP Q14330.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2384898
IUPHAR	89
DrugBank	BE0002304

Ligand

Name	NSC610996
Molecular formula	C18H16N2OS
IUPAC name	3,3-diphenyl-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-2-one
Molecular weight	308.399
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.6
Synonyms	AC1L77LF CHEMBL3220949 3,3-Diphenyl-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-2(3H)-one ZINC1611635 AC1Q6ION NSC-610996 3,3-diphenyl-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-2-one [ Show all ]
Inchi Key	ZFEOUZINYPNLSJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H16N2OS/c21-16-18(14-8-3-1-4-9-14,15-10-5-2-6-11-15)20-12-7-13-22-17(20)19-16/h1-6,8-11H,7,12-13H2
PubChem CID	356017
ChEMBL	CHEMBL3220949
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	11.0 %	MedChemComm, (2014) 5:5:632	ChEMBL
IC50	<10000.0 nM	MedChemComm, (2014) 5:5:632	ChEMBL
Inhibition	0.0 %	MedChemComm, (2014) 5:5:632	ChEMBL

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