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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Rattus norvegicus (Rat)
Gene	Htr2c
Synonym	5-HT-1C serotonin 1c receptor HTR1C 5-hydroxytryptamine receptor 1C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-HTR2C 5-HT2C receptor 5-HT2C 5-HT1C 5-HT-2C serotonin receptor 2C [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProt	P08909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL324
IUPHAR	8
DrugBank	BE0004882

Ligand

Name	trifluoperazine
Molecular formula	C21H24F3N3S
IUPAC name	10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine
Molecular weight	407.499
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	5.0
Synonyms	KBio2_000530 Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)- 5858-EP2302003A1 KBio2_007567 RP 7623 AC1Q3ZYE KBioSS_000530 Spectrum2_000828 BIDD:PXR0132 LS-105595 Stelazine (Salt/Mix) BPBio1_001345 MolPort-001-727-956 TFP BSPBio_002928 NCGC00013226-07 Trifluoperazine (INN) Trifluoroperazine DB00831 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-phenothiazin Triftazine (Salt/Mix) Fluoperazine (Salt/Mix) NCGC00024251-05 10-[3-(4-Methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine ZEWQUBUPAILYHI-UHFFFAOYSA-N HMS3429O07 NINDS_000843 10-[3-(4-methylpiperazino)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride 117-89-5 KBio2_003098 Prestwick0_000313 AB00053558 KBio3_002148 SCHEMBL24866 AN-22776 KSC-210-031 Spectrum5_001553 Bio1_001436 MLS001146870 Stellazine BRD-K89732114-001-05-9 NCGC00013226-02 Trifluoperazin HCl Calmazine NCGC00013226-10 Trifluoperazine [INN:BAN] cid_5566 Triflurin EINECS 204-219-4 10-(3-(4-methylpiperazin-1-yl)propyl)-2-(trifluoromethyl)-10H-phenothiazine Triphtazin GTPL214 NCI17474 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE IDI1_002190 NSC 46061 KB-217586 PDSP1_001300 KBio2_005666 Prestwick3_000313 AB00053558_29 KBioGR_000835 SPBio_000755 AX8155275 Lopac-T-8516 Stelazine Biomol-NT_000060 Modalina Terfluzine (Salt/Mix) BSPBio_000306 NCGC00013226-05 Trifluoperazina [Italian] CCRIS 6994 NCGC00013226-13 Trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine D0R4OM 10-(.gamma.-(N'-Methylpiperazino)propyl)-2-trifluoromethylphenothiozine Triftazin (Salt/Mix) Eskazinyl (TN) NCGC00024251-03 10-(gamma-(N'-Methylpiperazino)propyl)-2-trifluoromethylphenothiazine Triphthazine (Salt/Mix) HMS1990L11 NCIStruc1_001127 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine KBio2_001148 Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)- 5858-EP2309505A1 KBio3_000959 SBI-0051199.P003 AJ-73370 KBioSS_001148 Spectrum3_001374 Bio1_000458 M989 Stelazine (TN) BRD-K89732114-001-02-6 MRF-0000088 Trifluoperaz (TN) C07168 NCGC00013226-08 Trifluoperazine HCl CHEMBL422 Trifluoroperazine dihydrochloride DivK1c_000843 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-phenothiazine Triperazine Flurazine NCGC00024251-06 10-[3-(4-Methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine # ZINC19418959 HSDB 3195 Novo-Trifluzine 10H-Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)- NSC-17474 2-Trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine KBio2_003716 Prestwick1_000313 AB00053558-27 KBio3_002910 SKF 5019 Apo-Trifluoperazine KUC109776N Spectrum_000668 Bio2_000435 MLS002702821 STK182873 BRD-K89732114-300-05-5 NCGC00013226-03 Trifluoperazina CAS-440-17-5 NCGC00013226-11 Trifluoperazinum cMAP_000048 Trifluroperizine Eskazine 10-(gamma-(n inverted exclamation mark -methylpiperazino)propyl)-2-trifluoromethylphenothiazine Triphtazine HMS1362L11 NCI60_001427 10-[3-(4-methylpiperazin-1-yl)-propyl]-2-trifluoromethylphenothiazine Jatroneural (Salt/Mix) KBio1_000843 PDSP2_001284 214IZI85K3 KBio2_006284 QTL1_000085 AC1L1KMT KBioGR_002431 SPBio_002525 BDBM79181 Lopac0_001232 Stelazine (Dihydrochloride) BPBio1_000338 Modalina (TN) Terfluzine (TN) BSPBio_001190 NCGC00013226-06 CHEBI:45951 NCGC00013226-15 Trifluoromethylperazine 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine Triftazine Fluoperazine NCGC00024251-04 10-(gamma-(N'-Methylpiperazino)propyl)-2-trifluoromethylphenothiozine UNII-214IZI85K3 HMS2089J11 NCIStruc2_001093 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride 10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)- KBio2_002431 PMS Trifluoperazine KBio3_000960 SC-95890 AKOS001487920 KBioSS_002437 Spectrum4_000368 Bio1_000947 MCULE-3726407978 Stelazine Concentrate BRD-K89732114-001-03-4 NCGC00013226 Trifluoperazin C21H24F3N3S NCGC00013226-09 Trifluoperazine hydrochloride cid_2913535 Trifluperazine DTXSID1046928 10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)phenothiazine Tripfluoperazine Hydrochloride FT-0650159 NCGC00024251-07 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride IDI1_000843 NSC 17474 NSC17474 2-Trifluoromethyl-10-[3'-(1-methyl-4-piperazinyl)propyl]phenothiazine KBio2_004999 Prestwick2_000313 AB00053558_28 KBioGR_000530 SMR001566649 Apo-trifluoperazine (TN) L001075 SR-01000003020-6 Bio2_000915 MLS006011857 Synklor (Salt/Mix) BRD-K89732114-300-07-1 NCGC00013226-04 Trifluoperazina [INN-Spanish] CCG-37306 NCGC00013226-12 Trifluoperazinum [INN-Latin] D08636 Triftazin Eskazine (TN) 10-(gamma-(n inverted exclamation mark -methylpiperazino)propyl)-2-trifluoromethylphenothiozine Triphthasine HMS1792L11 NCI60_004087 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine Jatroneural (TN) [ Show all ]
Inchi Key	ZEWQUBUPAILYHI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3
PubChem CID	5566
ChEMBL	CHEMBL422
IUPHAR	214
BindingDB	79181
DrugBank	DB00831
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	100.0 nM	PMID7908055	BindingDB

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