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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Thromboxane A2 receptor
Species	Rattus norvegicus (Rat)
Gene	Tbxa2r
Synonym	prostanoid TP receptor TP receptor TXA2-R TXR2
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MWLNSTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAVVASQHAALLDWRATDPGCRLCHFMGAAMVFFGLCPLLLGAAMAAERFVGITRPFSRPAATSRRAWATVGLVWVGAGTLGLLPLLGLGRYSVQYPGSWCFLTLGAERGDVAFGLMFALLGSVSVGLSLLLNTVSVATLCRVYHAREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFILQTLLQTLPVMSPSGQLLRTTERQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFTSQLQAVSLHSPPTQAMLSGP
UniProt	P34978
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3156
IUPHAR	346
DrugBank	N/A

Ligand

Name	CHEMBL131036
Molecular formula	C17H15ClNO5S-
IUPAC name	2-[2-[[(4-chlorophenyl)sulfonylamino]methyl]-2,3-dihydro-1-benzofuran-5-yl]acetate
Molecular weight	380.819
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.4
Synonyms	Sodium; {2-[(4-chloro-benzenesulfonylamino)-methyl]-2,3-dihydro-benzofuran-5-yl}-acetate BDBM50075085
Inchi Key	CHYQHAXYRFWVMT-UHFFFAOYSA-M
Inchi ID	InChI=1S/C17H16ClNO5S/c18-13-2-4-15(5-3-13)25(22,23)19-10-14-9-12-7-11(8-17(20)21)1-6-16(12)24-14/h1-7,14,19H,8-10H2,(H,20,21)/p-1
PubChem CID	91931043
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50075085
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	141.0 nM	PMID10091692	BindingDB

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