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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Rattus norvegicus (Rat)
Gene	Chrm4
Synonym	cholinergic receptor cholinergic receptor, muscarinic 4 Chrm-4 HM3 M4 receptor
Disease	N/A for non-human GPCRs
Length	478
Amino acid sequence	MXNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProt	P08485
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL317
IUPHAR	16
DrugBank	N/A

Ligand

Name	CHEMBL256202
Molecular formula	C18H28ClN3O
IUPAC name	N-[3-chloro-4-(4-ethylpiperazin-1-yl)phenyl]hexanamide
Molecular weight	337.892
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.9
Synonyms	MLS000050295 BDBM50373835 N-[3-chloro-4-(4-ethylpiperazin-1-yl)phenyl]hexanamide HMS2461P17 ZINC2592963 AC1M17XR MolPort-002-273-274 REGID_for_CID_2066745 MCULE-1833722998 AKOS003214187 N-[3-chloro-4-(4-ethyl-1-piperazinyl)phenyl]hexanamide SMR000077492 [ Show all ]
Inchi Key	YYYAVCKEQQNXIB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H28ClN3O/c1-3-5-6-7-18(23)20-15-8-9-17(16(19)14-15)22-12-10-21(4-2)11-13-22/h8-9,14H,3-7,10-13H2,1-2H3,(H,20,23)
PubChem CID	2066745
ChEMBL	CHEMBL256202
IUPHAR	N/A
BindingDB	50373835
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5100.0 nM	PMID18178088	BindingDB,ChEMBL

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