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GPCR

NameType-1 angiotensin II receptor
SpeciesCavia porcellus (Guinea pig)
GeneAGTR1
SynonymAngiotensin II type-1 receptor
AT1
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMILNSSTEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTKMSTLSYRPSDNVSSSAKKPVQCFEVE
UniProtQ9WV26
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1671613
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL128397
Molecular formulaC26H23N5O2
IUPAC name2-ethyl-8-methoxy-4-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methoxy]quinoline
Molecular weight437.503
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP5.3
Synonyms4-[[2'-(1H-Tetrazol-5-yl)-1,1'-biphenyl-4-yl]methoxy]-2-ethyl-8-methoxyquinoline
2-Ethyl-8-methoxy-4-[2''-(1H-tetrazol-5-yl)-biphenyl-4-ylmethoxy]-quinoline
BDBM50003396
Inchi KeyCHPCFSFJWCGLPM-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H23N5O2/c1-3-19-15-24(22-9-6-10-23(32-2)25(22)27-19)33-16-17-11-13-18(14-12-17)20-7-4-5-8-21(20)26-28-30-31-29-26/h4-15H,3,16H2,1-2H3,(H,28,29,30,31)
PubChem CID10005096
ChEMBLCHEMBL128397
IUPHARN/A
BindingDB50003396
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50960.0 nMPMID1433210BindingDB,ChEMBL

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