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GPCR

NamePlatelet-activating factor receptor
SpeciesRattus norvegicus (Rat)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProtP46002
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4127
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL132824
Molecular formulaC26H26N4O
IUPAC name3-[4-(2,2-diphenylacetyl)piperazin-1-yl]-2-pyridin-3-ylpropanenitrile
Molecular weight410.521
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP3.1
Synonyms2-(3-Pyridinyl)-3-[4-(1-oxo-2,2-diphenylethyl)-1-piperazinyl]propanenitrile
BDBM50003476
SCHEMBL9852996
3-(4-Diphenylacetyl-piperazin-1-yl)-2-pyridin-3-yl-propionitrile; hydrate
Inchi KeyCGVOBRGBNOENDQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H26N4O/c27-18-24(23-12-7-13-28-19-23)20-29-14-16-30(17-15-29)26(31)25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,19,24-25H,14-17,20H2
PubChem CID10409305
ChEMBLCHEMBL132824
IUPHARN/A
BindingDB50003476
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ID50<5.0 mg.kg-1PMID1433215ChEMBL

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