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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Lysophosphatidic acid receptor 2
Species	Homo sapiens (Human)
Gene	LPAR2
Synonym	endothelial differentiation gene 4, lysophosphatidic acid G-protein-coupled receptor 4 LPA receptor 2 LPA-2 Edg4 Lysophosphatidic acid receptor Edg-4 Pbx4 pre-B-cell leukemia transcription factor 4 LPA2 receptor [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
UniProt	Q9HBW0
Protein Data Bank	N/A
GPCR-HGmod model	Q9HBW0
3D structure model	This predicted structure model is from GPCR-EXP Q9HBW0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3724
IUPHAR	273
DrugBank	N/A

Ligand

Name	1-Hexadecanoyl-sn-glycero-3-phosphate
Molecular formula	C19H39O7P
IUPAC name	[(2R)-2-hydroxy-3-phosphonooxypropyl] hexadecanoate
Molecular weight	410.488
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	5.0
Synonyms	1-palmitoyl-sn-glycerol-3-phosphate CHEMBL364797 Lysophosphatidic acid(16:0/0:0) 7220-34-0 Hexadecanoic acid, 2-hydroxy-3-(phosphonooxy)propyl ester, (R)- Palmitin, 1-mono-, 3-(dihydrogen phosphate), L- CHEBI:15799 LysoPA(16:0/0:0) ZINC8219000 1-Palmitoyl-sn-glyceryl 3-phosphate CTK2H2733 NKO AC1O4WBH LMGP10050006 Palmitoyl lysophosphatidic acid (2R)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate Lysophosphatidic acid(16:0) [(2R)-2-hydroxy-3-phosphonooxypropyl] hexadecanoate 1-palmitoyl-sn-glycerol 3-phosphate Hexadecanoic acid, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester PA(16:0/0:0) BDBM50430013 LPA(16:0/0:0) SCHEMBL2935665 (2R)-2-hydroxy-3-(phosphonooxy)propyl palmitate [ Show all ]
Inchi Key	YNDYKPRNFWPPFU-GOSISDBHSA-N
Inchi ID	InChI=1S/C19H39O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(21)25-16-18(20)17-26-27(22,23)24/h18,20H,2-17H2,1H3,(H2,22,23,24)/t18-/m1/s1
PubChem CID	6419701
ChEMBL	CHEMBL364797
IUPHAR	N/A
BindingDB	50430013
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	288.4 nM	PMID23395664	ChEMBL
EC50	290.0 nM	PMID23395664	BindingDB,ChEMBL
Intrinsic activity	0.092 -	PMID23395664	ChEMBL

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