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Name | Somatostatin receptor type 4 |
---|---|
Species | Homo sapiens (Human) |
Gene | SSTR4 |
Synonym | SS4R SS4-R SS-4-R SRIF2B SST4 receptor |
Disease | N/A |
Length | 388 |
Amino acid sequence | MSAPSTLPPGGEEGLGTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRHWPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAIFADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRFFQRVLCLRCCLLEGAGGAEEEPLDYYATALKSKGGAGCMCPPLPCQQEALQPEPGRKRIPLTRTTTF |
UniProt | P31391 |
Protein Data Bank | N/A |
GPCR-HGmod model | P31391 |
3D structure model | This predicted structure model is from GPCR-EXP P31391. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1853 |
IUPHAR | 358 |
DrugBank | BE0009273 |
Name | CHEMBL439077 |
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Molecular formula | C63H76N12O12S2 |
IUPAC name | (4R,7S,10S,13S,16S,19S,22R,25S)-13-(4-aminobutyl)-25-[[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-19-[(4-aminophenyl)methyl]-7,22-dibenzyl-10-[(1S)-1-hydroxyethyl]-16-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacosane-4-carboxylic acid |
Molecular weight | 1257.49 |
Hydrogen bond acceptor | 17 |
Hydrogen bond donor | 15 |
XlogP | 1.4 |
Synonyms | BDBM50136804 |
Inchi Key | CGKCQZCBEXFSFW-NHHOLAQASA-N |
Inchi ID | InChI=1S/C63H76N12O12S2/c1-36(76)54-62(85)72-50(30-38-14-6-3-7-15-38)59(82)74-53(63(86)87)35-89-88-34-52(73-55(78)45(66)28-39-21-25-43(77)26-22-39)61(84)70-48(29-37-12-4-2-5-13-37)57(80)69-49(31-40-19-23-42(65)24-20-40)58(81)71-51(32-41-33-67-46-17-9-8-16-44(41)46)60(83)68-47(56(79)75-54)18-10-11-27-64/h2-9,12-17,19-26,33,36,45,47-54,67,76-77H,10-11,18,27-32,34-35,64-66H2,1H3,(H,68,83)(H,69,80)(H,70,84)(H,71,81)(H,72,85)(H,73,78)(H,74,82)(H,75,79)(H,86,87)/t36-,45+,47-,48+,49-,50-,51-,52+,53-,54-/m0/s1 |
PubChem CID | 44368190 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50136804 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 1.2 nM | PMID14667214 | BindingDB |
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