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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL140514
Molecular formula	C21H28FNO
IUPAC name	[4-(4-fluorophenyl)-2,6-di(propan-2-yl)-5-propylpyridin-3-yl]methanol
Molecular weight	329.459
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.4
Synonyms	CGERYLIZDURBOY-UHFFFAOYSA-N SCHEMBL2647635 [4-(4-Fluoro-phenyl)-2,6-diisopropyl-5-propyl-pyridin-3-yl]-methanol 2,6-Diisopropyl-3-hydroxymethyl-4-(4-fluorophenyl)-5-propylpyridine BDBM50109323 2,6-Diisopropyl-4-(4-fluorophenyl)-5-propylpyridine-3-methanol [ Show all ]
Inchi Key	CGERYLIZDURBOY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H28FNO/c1-6-7-17-19(15-8-10-16(22)11-9-15)18(12-24)21(14(4)5)23-20(17)13(2)3/h8-11,13-14,24H,6-7,12H2,1-5H3
PubChem CID	22005204
ChEMBL	CHEMBL140514
IUPHAR	N/A
BindingDB	50109323
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	400.0 nM	PMID11814820	BindingDB,ChEMBL

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