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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	GSK-256073
Molecular formula	C10H13ClN4O2
IUPAC name	8-chloro-3-pentyl-7H-purine-2,6-dione
Molecular weight	256.69
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	2.3
Synonyms	1VI94C980K CHEMBL3730241 GSK-256073-A HM74A receptor agonists (hyperlipidemia), GSK DTXSID80673110 CGAMDQCXAAOFSR-UHFFFAOYSA-N GSK 256073 8-CHLORO-3-PENTYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE CTK5F6455 GSK256073 SCHEMBL2473169 862892-90-8 G protein-coupled receptor agonists (hyperlipidemia), GSK 1H-Purine-2,6-dione, 8-chloro-3,9-dihydro-3-pentyl- 8-chloro-3-pentyl-7H-purine-2,6-dione D04ODO GTPL8470 UNII-1VI94C980K AKOS030560051 GPCR agonists (hyperlipidemia), GSK [ Show all ]
Inchi Key	CGAMDQCXAAOFSR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H13ClN4O2/c1-2-3-4-5-15-7-6(12-9(11)13-7)8(16)14-10(15)17/h2-5H2,1H3,(H,12,13)(H,14,16,17)
PubChem CID	46215799
ChEMBL	CHEMBL3730241
IUPHAR	8470
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	31.6228 nM	PMID25773497	IUPHAR
EC50	>12589.2 nM	None	ChEMBL
Efficacy	<30.0 %	None	ChEMBL

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