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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	3-hydroxy-5-methylbenzoic acid
Molecular formula	C8H8O3
IUPAC name	3-hydroxy-5-methylbenzoic acid
Molecular weight	152.149
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.5
Synonyms	BDBM50391819 CTK3J4996 KSC494S9N S-5999 Z1255523409 3-hydroxy-5-methylbenzoicacid AB0030856 AK-47209 CFXOUQXGRQXUSE-UHFFFAOYSA-N EN300-84081 NSC-28456 STL555376 3-HYDROX-5-METHYLBENZOIC ACID 4CH-003267 AC-944 AN-15441 BBL101580 CL8088 KB-32167 QC-10603 W-203198 585-81-9 ACT07354 Benzoic acid, 3-hydroxy-5-methyl- DB-072503 MCULE-6111297909 SCHEMBL987044 ZINC1646464 3-methyl-5-hydroxy-benzoic acid AB1007712 AKOS005259855 ANW-48428 FS-2415 NSC28456 SY012261 3-Hydroxy-5-methyl benzoic acid 5-Hydroxy-m-toluic acid AC1L5MDH BC203205 CS-0030557 KS-00000NMY RTR-033310 X3116 3-hydroxy-5-methylbenzoic aicd 585H819 AJ-28686 BR-47209 DTXSID00207219 MolPort-005-933-293 ST2417734 3,5-Cresotic acid 3-methyl-5-oxidanyl-benzoic acid AB52735 AM84165 AW5 CHEMBL2146905 FT-0757074 PubChem18175 TR-033310 3-Hydroxy-5-methyl-benzoic acid AC1Q5TRP [ Show all ]
Inchi Key	CFXOUQXGRQXUSE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H8O3/c1-5-2-6(8(10)11)4-7(9)3-5/h2-4,9H,1H3,(H,10,11)
PubChem CID	231756
ChEMBL	CHEMBL2146905
IUPHAR	N/A
BindingDB	50391819
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<1000000.0 nM	PMID24900524	BindingDB,ChEMBL

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