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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	CHEMBL267853
Molecular formula	C17H18ClN5
IUPAC name	3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]imidazo[1,2-a]pyrimidine
Molecular weight	327.816
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.2
Synonyms	BDBM50073808 1-(4-chlorophenyl)-4-({imidazo[1,2-a]pyrimidin-3-yl}methyl)piperazine MCULE-8669888631 ZINC25973011 221470-64-0 MolPort-028-783-866 AKOS033429972 3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-imidazo[1,2-a]pyrimidine Z1562961320 [ Show all ]
Inchi Key	CFXIWIZPWMZACA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H18ClN5/c18-14-2-4-15(5-3-14)22-10-8-21(9-11-22)13-16-12-20-17-19-6-1-7-23(16)17/h1-7,12H,8-11,13H2
PubChem CID	44264622
ChEMBL	CHEMBL267853
IUPHAR	N/A
BindingDB	50073808
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	290.0 nM	PMID9990464	BindingDB,ChEMBL

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