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GLASS

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GPCR

Name	Metabotropic glutamate receptor 8
Species	Homo sapiens (Human)
Gene	GRM8
Synonym	mGluR8b mGluR8 mGlu8 receptor Gprc1h glutamate receptor GLUR8 [ Show all ]
Disease	N/A
Length	908
Amino acid sequence	MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
UniProt	O00222
Protein Data Bank	6bsz, 6bt5, 6e5v
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 6bsz.
BioLiP	BL0432251,BL0432252, BL0403876,BL0403877, BL0403874,BL0403875
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3228
IUPHAR	296
DrugBank	BE0000835

Ligand

Name	(1S,3R)-ACPD
Molecular formula	C7H11NO4
IUPAC name	(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid
Molecular weight	173.168
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-3.2
Synonyms	149881-50-5 ACPD CB 1712 D04DKM HMS3260C16 MLS002153209 SCHEMBL179741 (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid Tox21_500097 1,3-Cyclopentanedicarboxylic acid, 1-amino-, (1S-cis)- trans-(y)-ACPD 1-amino-1,3-dicarboxycyclopentane, cis-(1S,3S)-isomer 1-Aminocyclopentane-1S,3R-dicarboxylic acid B6220 CHEMBL34453 FT-0639513 J-500447 NCGC00024488-04 SR-01000075420-1 trans-( inverted question mark)-ACPD 1-Amino-1,3-dicarboxycyclopentane YFYNOWXBIBKGHB-FBCQKBJTSA- 130942-93-7 AC1L2XGH BN0051 cis-ACPD FT-0695378 LP00097 PDSP1_000813 SR-01000597678-2 (trans)-1-aminocyclopentyl-1,3-dicarboxylate trans-(1S,3R)-ACPD 1-amino-1,3-dicarboxycyclopentane, (trans)-isomer 1S,3R-ACPD ACPD-1S,3R CCG-204192 EU-0100097 I04-8357 MolPort-003-940-060 SMR001230688 (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid;hydrate trans-( )-ACPD monohydrate 1,3-Cyclopentanedicarboxylicacid, 1-amino-, (1S,3R)- trans-1-aminocyclopentane-1,3-dicarboxylate 1-amino-1,3-dicarboxycyclopentane, trans-(1R,3S)-isomer 1-aminocyclopentyl-1,3-dicarboxylic acid 67684-64-4 B6245 cid_16218853 FT-0639514 J-500459 NCGC00024488-05 SR-01000597678 (1S,3S)-1-amino-1,3-cyclopentanedicarboxylic acid trans-(+/-)-ACPD 1-amino-1,3-dicarboxycyclopentane, (cis)-(+-)-isomer ZINC2004213 AC1Q5QYM C5b CTK0H3900 GTPL1365 LS-57947 PDSP2_000800 (1S,3R)-1-ACPD t-ACPD 1,3-Cyclopentanedicarboxylic acid, 1-amino-, (1S,3R)- trans-(?)-ACPD 1-amino-1,3-dicarboxycyclopentane, cis-(1R,3R)-isomer 27-84-9 AKOS017344535 FCH839908 InChI=1/C7H11NO4/c8-7(6(11)12)2-1-4(3-7)5(9)10/h4H,1-3,8H2,(H,9,10)(H,11,12)/t4-,7+/m1/s1 NCGC00024488-03 SR-01000075420 (1S,3R)-1-azanylcyclopentane-1,3-dicarboxylic acid;hydrate trans-( inverted question mark)-1-Amino-1,3-cyclopentanedicarboxylic acid 1-Amino-1,3-cyclopentanedicarboxylic acid trans-ACPD 1-amino-cyclopentyl-trans-1S,3R-dicarboxylate 111900-32-4 A-155 BDBM66976 cis-1-amino-1,3-cyclopentanecarboxylic acid FT-0695375 Lopac0_000097 NCGC00260782-01 SR-01000597678-1 (1S,3S)-ACPD trans-(1S,3R)-1-Amino-1,3-cyclopentanedicarboxylic acid 1-amino-1,3-dicarboxycyclopentane, (trans)-(+-)-isomer [ Show all ]
Inchi Key	YFYNOWXBIBKGHB-FBCQKBJTSA-N
Inchi ID	InChI=1S/C7H11NO4/c8-7(6(11)12)2-1-4(3-7)5(9)10/h4H,1-3,8H2,(H,9,10)(H,11,12)/t4-,7+/m1/s1
PubChem CID	104766
ChEMBL	CHEMBL34453
IUPHAR	1365
BindingDB	66976
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	45000.0 nM	PMID12166935	ChEMBL
EC50	39810.7 nM	PMID9473604	IUPHAR
Ki	45000.0 nM	PMID10893301	BindingDB,ChEMBL

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