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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
TaR-7b
Trace amine receptor 12
Trace amine receptor 7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3641749
Molecular formulaC14H15ClN4O
IUPAC name6-chloro-N-[4-[(2R)-morpholin-2-yl]phenyl]pyrimidin-4-amine
Molecular weight290.751
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.1
SynonymsUS8802673, 199
BDBM129557
SCHEMBL12610070
Inchi KeyCFKXGLIQCYTCIX-LBPRGKRZSA-N
Inchi IDInChI=1S/C14H15ClN4O/c15-13-7-14(18-9-17-13)19-11-3-1-10(2-4-11)12-8-16-5-6-20-12/h1-4,7,9,12,16H,5-6,8H2,(H,17,18,19)/t12-/m0/s1
PubChem CID86766844
ChEMBLCHEMBL3641749
IUPHARN/A
BindingDB129557
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki56.0 nM, NoneBindingDB,ChEMBL

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