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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Homo sapiens (Human)
Gene	NPY5R
Synonym	NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor Y5 receptor [ Show all ]
Disease	Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity
Length	445
Amino acid sequence	MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProt	Q15761
Protein Data Bank	N/A
GPCR-HGmod model	Q15761
3D structure model	This predicted structure model is from GPCR-EXP Q15761.
BioLiP	N/A
Therapeutic Target Database	T20331
ChEMBL	CHEMBL4561
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL521844
Molecular formula	C21H15ClF2N2
IUPAC name	2-(2-chlorophenyl)-5,5-bis(4-fluorophenyl)-1,4-dihydroimidazole
Molecular weight	368.812
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.7
Synonyms	2-(2-chlorophenyl)-4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazole BDBM50257788
Inchi Key	CEWAFXCNDQBSHL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H15ClF2N2/c22-19-4-2-1-3-18(19)20-25-13-21(26-20,14-5-9-16(23)10-6-14)15-7-11-17(24)12-8-15/h1-12H,13H2,(H,25,26)
PubChem CID	44573408
ChEMBL	CHEMBL521844
IUPHAR	N/A
BindingDB	50257788
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	630.0 nM	PMID19233647	BindingDB,ChEMBL

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