You can:
Name | Growth hormone secretagogue receptor type 1 |
---|---|
Species | Homo sapiens (Human) |
Gene | GHSR |
Synonym | ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor [ Show all ] |
Disease | N/A |
Length | 366 |
Amino acid sequence | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT |
UniProt | Q92847 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q92847 |
3D structure model | This predicted structure model is from GPCR-EXP Q92847. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4616 |
IUPHAR | 246 |
DrugBank | BE0003383 |
Name | CHEMBL121803 |
---|---|
Molecular formula | C29H40N4O4 |
IUPAC name | (E)-5-amino-N,5-dimethyl-N-[(2R)-1-[methyl-[(2R)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylmethoxypropan-2-yl]hex-2-enamide |
Molecular weight | 508.663 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 2.4 |
Synonyms | SCHEMBL6317099 (E)-5-Amino-5-methyl-hex-2-enoic acid {(R)-2-benzyloxy-1-[methyl-((R)-1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-ethyl}-methyl-amide SCHEMBL6317105 BDBM50066811 N-(5-Amino-5-methyl-2-hexenoyl)-N-methyl-O-Bzl-D-Ser-N-methyl-D-Phe-NHMe |
Inchi Key | XWYYKUODLCJVGU-CHPXNICDSA-N |
Inchi ID | InChI=1S/C29H40N4O4/c1-29(2,30)18-12-17-26(34)32(4)25(21-37-20-23-15-10-7-11-16-23)28(36)33(5)24(27(35)31-3)19-22-13-8-6-9-14-22/h6-17,24-25H,18-21,30H2,1-5H3,(H,31,35)/b17-12+/t24-,25-/m1/s1 |
PubChem CID | 10649323 |
ChEMBL | CHEMBL121803 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Cmax_[GH] | 0.4 ng ml-1 | PMID9733496 | ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417