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GPCR

NamePlatelet-activating factor receptor
SpeciesRattus norvegicus (Rat)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProtP46002
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4127
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL318163
Molecular formulaC24H27N5O3
IUPAC name2-(2-methylpyridin-3-yl)-2-[4-[3-(2-oxo-1,3-oxazolidin-3-yl)-3-phenylpropanoyl]piperazin-1-yl]acetonitrile
Molecular weight433.512
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP1.5
SynonymsBDBM50045986
SCHEMBL9575001
(2-Methyl-pyridin-3-yl)-{4-[3-(2-oxo-oxazolidin-3-yl)-3-phenyl-propionyl]-piperazin-1-yl}-acetonitrile
[4-[3-Phenyl-1-oxo-3-(2-oxooxazolidin-3-yl)propyl]piperazin-1-yl](2-methyl-3-pyridyl)acetonitrile
Inchi KeyCETMEQRKGQVKGS-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H27N5O3/c1-18-20(8-5-9-26-18)22(17-25)27-10-12-28(13-11-27)23(30)16-21(19-6-3-2-4-7-19)29-14-15-32-24(29)31/h2-9,21-22H,10-16H2,1H3
PubChem CID10252309
ChEMBLCHEMBL318163
IUPHARN/A
BindingDB50045986
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ID500.029 mg.kg-1PMID8411016ChEMBL

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