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GLASS

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GPCR

Name	Cholecystokinin receptor type A
Species	Rattus norvegicus (Rat)
Gene	Cckar
Synonym	CCK-A receptor CCK-AR CCK1 receptor CCK1-R cholecystokinin receptor type A cholecystokinin-1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP
UniProt	P30551
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2871
IUPHAR	76
DrugBank	N/A

Ligand

Name	diazepam
Molecular formula	C16H13ClN2O
IUPAC name	7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Molecular weight	284.743
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.0
Synonyms	Methyldiazepinone (pharmaceutical) Dipezona NCGC00178168-01 DSSTox_GSID_20406 neurolytr il e-Pam Novo-Dipam Faustan Ortopsique GTPL3364 Paxum I06-0194 Pro pam KBioGR_001012 Quievita Lamra Ro-52807 Mandro-Zep Diazepamum [INN-Latin] Bialzepam Setonil C06948 2H-1, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- Sonacon CC-26451 7-chloranyl-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Tensium CHEMBL12 7-chloro-1-methyl-5-phenyl-1,3-dihydro-[1,4]benzodiazepin-2-one Tranquase D0Y1YC 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Usempax ap Dialar AKOS003367969 Valrelease Diastat, Valium Ansilive Vivol Diazepam (JP17/USP/INN) Apozepam ZINC6427 Diazepam Intensol BCP0726000176 Diazepam, European Pharmacopoeia (EP) Reference Standard Sedapam Diazepin MLS000759402 Dizac NCGC00178168-04 Ducene Nivalen Eridan NSC-169897 Frustan Paralium HMS3393N04 Placidox 5 InChI=1/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H Q-pam Kratium 2 Relanium Liberetas Medipam Diazepam-Lipuro Seduxen BRD-K16508793-001-01-8 Sico Relax Calmociteno 439-14-5 Spectrum5_001890 Centrazepam 7-chloro-1-methyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one Tox21_113071_1 CPD000058398 7-Chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Tranquo-tablinen Desconet A826456 Valiquid Diapine Alupram Vatran Diazem Antenex WLN: T67 GNV JN IHJ CG G1 KR Diazepam Dak Assival Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material S.a. r.l. BDBM50000766 Methyl diazepinone Dipam Morosan Drenian Nerozen Duxen Notense Evacalm NSC77518 Gihitan Paxate HSDB 3057 Pms-Diazepam KBio1_000967 Quetinil LA-111 Ro 5-2805 LS-122 Diazepamu [Polish] Serenzin BSPBio_003279 1-Methyl-5-phenyl-7-chloro-1,4-benzodiazepin-2-one SMR000058398 CAS-439-14-5 53320-84-6 STK735517 CHEBI:49575 7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one Trankinon D00293 7-Chloro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one UNII-Q3JTX2Q7TU Diaceplex AC-10561 Valium (TN) Diastat (TN) An-Ding Velium Apaurin ZB000640 Diazepam Fabra Azedipamin Diazepam [USAN:INN:BAN:JAN] Saromet Best [Pharaceutical] Methyldiazepinone, pharmaceutical Disopam NCGC00178168-02 DSSTox_RID_75566 Neurolytril EINECS 207-122-5 Novodipam Faustan, Paceum Gubex Placidox 10 Iazepam Prozepam Kiatrium Radizepam Lembrol Ruhsitus Mandrozep Diazepan BIDD:GT0105 Sibazon Calmaven 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- Spectrum3_001780 CCG-100997 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H -1,4-benzodiazepin-2-one Tensopam Chuansuan 7-Chloro-1-methyl-5-phenyl-1,4-benzodiazepin-2-one Tranquirit DB00829 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one. Valaxona Diapam Alboral Valuzepam Diatran Ansiolin W-5055 Diazepam 0.1 mg/ml in Methanol Armonil Zipan Diazepam Nordic BCP23002 Diazepam, United States Pharmacopeia (USP) Reference Standard Sedipam Diazetard MLS001424086 Domalium NCGC00260007-01 Duksen Nixtensyn Euphorin P NSC-77518 FT-0632135 Paranten HMS503A15 Plidan Jinpanfan Q-Pam Relanium LA 111 Reliver Lizan Mentalium Diazepam-ratiopharm Serenack Britazepam (Z)-7-chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Simasedan Calmod 5-24-04-00300 (Beilstein Handbook Reference) Stesolid Cercine 7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine Tox21_202458 CS-0653 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one Trazepam Desloneg AAOVKJBEBIDNHE-UHFFFAOYSA-N Valitran Diaquel Amiprol Vazen Diazemuls Anxicalm Wy 3467 Diazepam Desitin Atensine Diazepam solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis S.A.R.L. Bensedin Methyldiazepinone Dipaz NC00247 DSSTox_CID_406 Nervium DZP Novazam Faustal Oprea1_126223 Gradual Paxel HY-17027 Pomin KBio3_002780 Quiatril La-Iii Ro 5-2807 Mandro Diazepamum Betapam Servizepam C-17931 11100-37-1 Solis Caudel 7 -chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one T-quil 7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one Tranqdyn D07JVL 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one Unisedil Dialag AC1L1EZE Valium R Diastat Acudial Anlin Vival Diazepam (intranasal, epilepsy) Apo-diazepam Zepaxid Diazepam for system suitability, European Pharmacopoeia (EP) Reference Standard Baogin Diazepam [USAN:USP:INN:BAN:JAN] SCHEMBL21442 Diazepan leo Metil Gobanal DivK1c_000967 NCGC00178168-03 DTXSID4020406 NINDS_000967 Elcion CR NSC 169897 Freudal Pacitran HMS2051N04 Placidox 2 IDI1_000967 Psychopax Kratium Relaminal Levium MCULE-8990989144 Seduksen BIDD:PXR0158 Sibazone Calmocitene Spectrum4_000576 CCRIS 6009 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Tox21_113071 Condition 7-chloro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2(3H)on Tranquo-puren DEA No. 2765 A3662/0155188 Valeo Diapax Aliseum Vanconin Diazapam Ansiolisina Winii Diazepam 1.0 mg/ml in Methanol Arzepam Diazepam Rectubes S.A. R.L BCP9000199 Diazepam-Eurogenerics Dienpax Mono (2-ethylhexyl) phthalate Doval Nellium Dupin Noan Eurosan NSC169897 Gewacalm Parzam Horizon Plumiaz Kabivitrum Q3JTX2Q7TU LA III Renborin Lovium Metamidol Diazepamu Serenamin BRN 0754371 1-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one Sipam Calmpose Stesolin Ceregulart 7-Chloro-1-methyl-5-3H-1,4-benzodiazepin-2(1H)-one Tranimul D-Pam 7-Chloro-1-methyl-5-phenyl-2-oxo-2,3-dihydro-1H-benzo[f]-1,4-diazepine Umbrium Diacepan AB02310 Valium Diastat AN-23449 Vazepam Diazemulus Anxionil WY-3467 Diazepam Elmu Atilen Diazepam Stada SAM001246536 Benzopin [ Show all ]
Inchi Key	AAOVKJBEBIDNHE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
PubChem CID	3016
ChEMBL	CHEMBL12
IUPHAR	3364
BindingDB	50000766
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<100000.0 nM	PMID2848124	BindingDB,ChEMBL

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