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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Homo sapiens (Human)
Gene	NPY5R
Synonym	NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor Y5 receptor [ Show all ]
Disease	Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity
Length	445
Amino acid sequence	MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProt	Q15761
Protein Data Bank	N/A
GPCR-HGmod model	Q15761
3D structure model	This predicted structure model is from GPCR-EXP Q15761.
BioLiP	N/A
Therapeutic Target Database	T20331
ChEMBL	CHEMBL4561
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL423720
Molecular formula	C16H18N6
IUPAC name	2-methyl-4-piperidin-1-yl-6-pyrazin-2-yl-5H-pyrrolo[3,2-d]pyrimidine
Molecular weight	294.362
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	1.7
Synonyms	BDBM50093634 SCHEMBL5774702 2-Methyl-4-piperidin-1-yl-6-pyrazin-2-yl-5H-pyrrolo[3,2-d]pyrimidine
Inchi Key	AFBPXILBVZLAET-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H18N6/c1-11-19-13-9-12(14-10-17-5-6-18-14)21-15(13)16(20-11)22-7-3-2-4-8-22/h5-6,9-10,21H,2-4,7-8H2,1H3
PubChem CID	10520484
ChEMBL	CHEMBL423720
IUPHAR	N/A
BindingDB	50093634
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1400.0 nM	PMID11063624	BindingDB,ChEMBL

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